Protein Alignment Cyp12a5 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 476
• Identity: 111/476 - (23%)
• Similarity: 209/476 - (43%)
• Gaps: 89/476 - (18%)

  Fly    91 LPGMMGRDGLVMTHNPKDFEVVFRN--------EGVWPFRPGSDILRYHRTV------------- 134
            :|| ..||...:.|:|....::..|        ..|..:.|...|...||.:
 Frog    39 IPG-PPRDSFFLGHSPTMLRLMKNNLLMYDHFLGWVQKYGPVVRINGLHRVIILVVSPEAVKELL 102

  Fly   135 ----YRKD-FFDGVQGI--IPSQGKS---------WGDFRSIVNPVLMQPKNVRLYFKKMSQVNQ 183
                |.|| |:|.:..:  :...||.         |...|.|::|...:...:.|    |...|:
 Frog   103 MSPKYSKDKFYDVIANMFGVRFMGKGLVTDRDYDHWHKQRRIMDPAFSRTYLMGL----MGPFNE 163

  Fly   184 EFVELIKEIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFF 248
            :..||::::.:.:..:......:.::|.||:.:..||...:|..|     |.:.|...|.:.  .
 Frog   164 KAEELMEKLMEKADGKCEIKMHDMLSRLTLDVIGKVAFGMELNSL-----NDDLTPFPKAIS--L 221

  Fly   249 LHSADLEMKPSLWRY--FKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSV 311
            :....:||:..:.||  .|...::|:..::..:::..    .|.|||.:|:.::|   .|....:
 Frog   222 VMKGIVEMRNPMVRYSLAKRGFIRKVQESIRLLRQTG----KECIERRQKQIQDG---EEIPVDI 279

  Fly   312 LEKLLK-------VDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPN 369
            |.::||       .|.::.....:...:||.:||::..:.:::.|.:|||...:.:.|:.:|:.:
 Frog   280 LTQILKGAAMEEECDPEILLDNFVTFFIAGQETTANQLSFVVMELGRNPEILEKAQAEIDEVIGS 344

  Fly   370 K-DSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLY- 432
            | |.|:.:  :..:.||...:||:.|:||...|.:||||.|.||.|.:||...   .|.:||..
 Frog   345 KRDIEYED--LGKLQYLSQVLKETLRLYPTAPGTSRGLTEDMVIDGVKVPENV---TIMLNSYIM 404

  Fly   433 --SEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELG 495
              .|:|:..|..|.|:|:..:|             .|..:.:.||..|||.|:|:...:||.::.
 Frog   405 GRMEQYYSDPLTFNPDRFSPDA-------------PKPYYSYFPFSLGPRSCIGQVFSQMEAKVV 456

  Fly   496 TARLIRNFNVEFNHSTKNAFR 516
            .|:|::.:  ||..:...:|:
 Frog   457 MAKLLQRY--EFELAEGQSFK 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	111/476 (23%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	104/448 (23%)