Protein Alignment Cyp12a5 and cyp27a1.3

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_002934001.3
• Gene: cyp27a1.3 / 594905
• XenbaseID: XB-GENE-18386061
• Length: 518
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 157/542 - (28%)
• Similarity: 254/542 - (46%)
• Gaps: 75/542 - (13%)

  Fly    23 QQRWQTNVPTAEIRNDP----------EWLQAKPFEEIPKANILSLFAKSALPGGKYKNLEMMEM 77
            ||..:.||.|  :|...          |....|..:::|..:.|.|.....|.|..::..|:..:
 Frog    15 QQSCRANVQT--VRKKATLGVSGATVVEGKTLKTLDDLPGPSPLKLLYWIFLRGYLFRTHELQVI 77

  Fly    78 IDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDG 142
               .::.||.:..:...  :..:|...:|...|.:.|.||.:|.|....|:|.||.:....:
 Frog    78 ---FKKTYGPMWKMSDR--QHAMVTVASPDLLESLLRKEGKYPTRADMFIMREHRDLRGHSY--- 134

  Fly   143 VQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEI--RDASTQEVPGNFL 205
              |.:..:|..|...|:|:|..:::|:...:|...|::|..:.:..|||:  :.:|..:|.| ..
 Frog   135 --GPVTEEGHQWHRIRTILNQRMLKPRETVVYAGSMNEVVSDLLLKIKELTAQSSSGTQVNG-VA 196

  Fly   206 ETINRWTLESVSVVALDKQLGLLRESGKNSE-ATKLFKYLDEFFLHSADLEMKPSL--WRYFKTP 267
            |.:.::..||:..|..:.:||.|     |.| ..:..|::|...:....|.|...|  |.....|
 Frog   197 ELMYKFAFESICTVLFETRLGCL-----NKEILPETQKFIDSIGIMLEHLTMLTRLPQWTKGILP 256

  Fly   268 LLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLL---KVDKKVATVMAMD 329
            ...:.:...|::.:...|.:|:.:|.:|...|.|   .|.|...|..||   |:..:......::
 Frog   257 YWGRYIEAWDTIFDFGKKLIDKKMEDIEGRLKRG---EEVEGEYLTYLLSSGKLSMEEVYGSVVE 318

  Fly   330 MLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNK---DSEFTEASMKNVPYLRACIKE 391
            :|.|||||||:|.|..|..|::|||.|..|.:||::|:|.:   |||    ::..:|.|:|.|||
 Frog   319 LLQAGVDTTSNTLTWALYQLSRNPEIQNNLYQEVIRVIPGETIPDSE----AIARMPLLKAVIKE 379

  Fly   392 SQRVYPLVIGNARGLTRDSV-ISGYRVPAGT--IVSMIPINSLYSEEYFPKPTEFLPERWLRNAS 453
            :.|::|:|..|||.:....| |..|..|..|  |:....|:.  .|..||:...||||||||
 Frog   380 TLRLFPVVPENARMINEKEVTIKDYVFPVKTQFILGHYAISR--DETTFPEADRFLPERWLR--- 439

  Fly   454 DSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNV-------EFNHST 511
            ||..|        .:||..:|||:|.|.|||:||.|:|:.|..:|:|:.|.|       |.  ..
 Frog   440 DSGMK--------HHPFGSIPFGYGVRACVGRRIAELEMHLALSRIIKMFQVIPDPDLGEV--GA 494

  Fly   512 KNAFRSALINLPNIPLKFKFTD 533
            ||  |:.|:  .|.|:..:|.:
 Frog   495 KN--RAVLV--ANRPVNLRFIE 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	142/466 (30%)
cyp27a1.3	XP_002934001.3	cytochrome_P450	79..508	CDD:477761	142/467 (30%)