DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a5 and si:dkey-91i10.3

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001116749.1	Gene:	si:dkey-91i10.3 / 565876	ZFINID:	ZDB-GENE-081105-124	Length:	513	Species:	Danio rerio

Alignment Length:	503	Identity:	137/503 - (27%)
Similarity:	237/503 - (47%)	Gaps:	54/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KPFEEIPKANILS----LFAKSALPGGKYKNLEMMEMIDAL-RQDYGNIIFLPGMMGRDGLVMTH 104
            |..:::...:.|:    ||.|..........:|..::...| :..||.::          :|...
Zfish    44 KTMDDLDGPSFLTSLYWLFGKGYFQTTHQMQIEHSKIYGPLWKSKYGPLV----------IVNVA 98

  Fly   105 NPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPK 169
            :....|.|.|.||..|.|....    |...||| ..:...|.:...|..|...|||:||.:::||
Zfish    99 SADLIEQVLRQEGRHPIRTDMP----HWRGYRK-LRNHAYGPLTEMGPEWQRIRSILNPRMLKPK 158

  Fly   170 NVRLYFKKMSQVNQEFVELIKEIR-----DASTQEVPGNFLETINRWTLESVSVVALDKQLGLLR 229
            :|..|...::.|..:|:|.:.:::     |....:|.|.    :.::..|.:|.|..:.::|.|.
Zfish   159 HVSNYTNAINGVVSDFIEKMAKLKTTKGNDVMVYDVAGE----LYKFAFEGISSVLFETRMGCLN 219

  Fly   230 ESGKNSEATKLFKY-LDEFFLHSADLEMKPS-LWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIE 292
            :  :..|.|:.|.: :.|.|..|..:.:.|. ||.|.  |..|..:...|.:.:|..:.|.:.:.
Zfish   220 D--EIPEETQKFIFSVGEMFRLSPIVILFPKFLWPYM--PFWKHFVAVWDHLFKVADELVQQKMT 280

  Fly   293 RLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMA--MDMLMAGVDTTSSTFTALLLCLAKNPEK 355
            .::::.|.|  .|...:.:...|:........|:.  .::|:|||||||:|.:..|..||:.||.
Zfish   281 EIQEKVKTG--SPVEGEYLTHLLISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEI 343

  Fly   356 QARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISG-YRVPA 419
            |.:|.|||:.|.|. |...:...:..:|.|:|.::|:.|:||:|.||||.:..:.::.| :..|.
Zfish   344 QQKLHEEVVSVCPG-DKTPSSDDITRMPLLKAIVRETLRLYPVVPGNARVVAENEIVVGDHLFPK 407

  Fly   420 GTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVG 484
            .|:..:......|.|..||.|..|||:||:|....          .:::||..:|||||.|.|:|
Zfish   408 NTLFHLCHFAVSYDETVFPDPFAFLPQRWIREQKQ----------LSQHPFGSVPFGFGIRACLG 462

  Fly   485 KRIVEMELELGTARLIRNFNVEFNHSTKNA---FRSALINLPNIPLKF 529
            :|:.|:|:.|..:|||:.:.|..:.|.|..   .|:.|:...:|.|:|
Zfish   463 RRVAELEMYLLLSRLIKRYEVRPDPSGKTVKPITRTLLVPATSIDLQF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	131/463 (28%)
si:dkey-91i10.3	NP_001116749.1	p450	52..510	CDD:278495	135/493 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880