DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a5 and si:ch211-113j14.1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_686522.4	Gene:	si:ch211-113j14.1 / 558239	ZFINID:	ZDB-GENE-120215-110	Length:	573	Species:	Danio rerio

Alignment Length:	430	Identity:	124/430 - (28%)
Similarity:	208/430 - (48%)	Gaps:	34/430 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 VFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFK 176
            |.|.||.:|.|  :|:  .|...|| |......||....|..|...||.:||.:::.|.|..|..
Zfish   164 VIRQEGRYPVR--TDL--PHWREYR-DMRGQAYGIHVDTGPEWYRIRSALNPKMLKLKEVTAYAP 223

  Fly   177 KMSQVNQEFVELIKEIRDASTQEVP-GNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKL 240
            .:.:|..:.::.::.:|..|..::. .:....:.::..|.:|.:..:.:||.|:|. ..::..:.
Zfish   224 IIHEVVSDLLQRLELLRLRSPDQITVSDLASELYKFGFEGISSILFETRLGCLQEE-IPTDTLRF 287

  Fly   241 FKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRP 305
            ...::|....|..:...|. |.....|..|:.::..|.:.:|....:|:.:    .|.::.|.|.
Zfish   288 ISAVNEMLALSETVLFFPR-WTRHIFPFWKRFVQAWDELYDVARHLIDKKV----NEIRDQVARG 347

  Fly   306 EHEQSVLEKLLKVDKKVAT----VMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKV 366
            |..:.:....|....|::.    :...::|:.||||||:|.:..|..||:|||.|.||..|::.|
Zfish   348 EEVEGMYLTYLLSSNKLSLGEVYISLTELLLGGVDTTSNTLSWTLYHLARNPEIQKRLHNEIVSV 412

  Fly   367 LPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDS--VISGYRVPAGTIVSMIPIN 429
            .|||....|: .:..:||::|.|||..|:||:|.||.| ||.||  |:..|..|..|...:....
Zfish   413 CPNKKVPNTD-DLTKMPYMKAVIKEILRMYPVVPGNGR-LTVDSDIVVDNYWFPKKTQFHLCHYA 475

  Fly   430 SLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELEL 494
            ..:.|..||....|:||||:|   ||..:      ...:|:..:|||.|.|.|||||:.|:|:..
Zfish   476 VSHDENNFPDAERFVPERWIR---DSPSR------SQHHPYSSVPFGVGVRACVGKRVAELEMYF 531

  Fly   495 GTARLIRNFNVEF---NHSTKNAFRSALINLPNIPLKFKF 531
            ..:||::.:.|..   :.|.:...|:.||  |:.|:..:|
Zfish   532 ALSRLMQQYEVRTKAGSPSIQPKTRTLLI--PSQPIDLQF 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	123/428 (29%)
si:ch211-113j14.1	XP_686522.4	p450	108..569	CDD:278495	123/428 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.780