DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and shd

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001261843.1	Gene:	shd / 39592	FlyBaseID:	FBgn0003388	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	134/473 - (28%)
Similarity:	232/473 - (49%)	Gaps:	25/473 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHR 132
            :||..::.|:...|.:.||:|: |..|.....:|..:|..|.|.|.:....:||||.::|:..:|
  Fly    83 RYKMTKLHEVYADLNRQYGDIV-LEVMPSNVPIVHLYNRDDLEKVLKYPSKYPFRPPTEIIVMYR 146

  Fly   133 TVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDAST 197
            . .|.|.:..| ||:..||..|...||.:...:..|:.::.:...::.|..:|:||::..||..|
  Fly   147 Q-SRPDRYASV-GIVNEQGPMWQRLRSSLTSSITSPRVLQNFLPALNAVCDDFIELLRARRDPDT 209

  Fly   198 QEVPGNFLETINRWTLESVSVVALDKQLGLLR-ESGKNSEATKLFKYLDEFFLHSADLEMKPSLW 261
            ..|| ||.|..|...||:|..:.|.:::|.|. ::.:..:.::|...:.:.|:...|......||
  Fly   210 LVVP-NFEELANLMGLEAVCTLMLGRRMGFLAIDTKQPQKISQLAAAVKQLFISQRDSYYGLGLW 273

  Fly   262 RYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKV------DK 320
            :||.|...:...|..|.:.:|..:.:|..:|.|:|.|..........:|:...:|::      ||
  Fly   274 KYFPTKTYRDFARAEDLIYDVISEIIDHELEELKKSAACEDDEAAGLRSIFLNILELKDLDIRDK 338

  Fly   321 KVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYL 385
            |.|.:   |.:.||::|.::|...:|..:..:|....|:..|..:.   :|:...:.::.|..|.
  Fly   339 KSAII---DFIAAGIETLANTLLFVLSSVTGDPGAMPRILSEFCEY---RDTNILQDALTNATYT 397

  Fly   386 RACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLR 450
            :|||:||.|:.|.....||.|..|..:|||.:.|||:|....:.:.:.:..|....:|.||||:.
  Fly   398 KACIQESYRLRPTAFCLARILEEDMELSGYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWID 462

  Fly   451 NASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAF 515
            .|:::.      .:...|..:.:|||.|.|.|.|||.||||:.|..|:::..|:|.|....:..|
  Fly   463 PATENF------TVNVDNASIVVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVSFVKPLETEF 521

  Fly   516 RSALINLPNIPLKFKFTD 533
            ...|  .|..||..:.:|
  Fly   522 EFLL--APKTPLSLRLSD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	130/456 (29%)
shd	NP_001261843.1	p450	63..528	CDD:299894	130/462 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920