Protein Alignment Cyp12a5 and Cyp12b2

DIOPT Version :9

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_611370.2
• Gene: Cyp12b2 / 37163
• FlyBaseID: FBgn0034387
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 211/511 - (41%)
• Similarity: 322/511 - (63%)
• Gaps: 15/511 - (2%)

  Fly    27 QTNVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFL 91
            ||.:..|:.|.|.:|.||:.|.|||..::|.:.: ..:|||..:|..:::|...:|:.||:|..:
  Fly    33 QTQLELADSRIDEKWQQARSFGEIPGPSLLRMLS-FFMPGGALRNTNLIQMNRLMREMYGDIYCI 96

  Fly    92 PGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGD 156
            |||||:...|.|:||.|||:.:|||||||.|.|.:.|.|:|.::|.|.|.||.|:...||:.|.|
  Fly    97 PGMMGKPNAVFTYNPDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWAD 161

  Fly   157 FRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLESVSVVAL 221
            .|:.||||||:.:|||....::.|:::||::.::..|:..|..:..:|...:..|..||:|.|||
  Fly   162 IRNKVNPVLMKVQNVRQNLPQLDQISKEFIDKLETQRNPETHTLTTDFHNQLKMWAFESISFVAL 226

  Fly   222 DKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKY 286
            :.::|||.:: .:..|.:|.|::.:||.:|...:::||:|.::||...||.|:|.|::.::|..|
  Fly   227 NTRMGLLSDN-PDPNADRLAKHMRDFFNYSFQFDVQPSIWTFYKTAGFKKFLKTYDNITDITSNY 290

  Fly   287 VDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAK 351
            ::.|:....|. .:|..:     .|||:||:.:||||..|.|||||||:|||||....:|..||:
  Fly   291 IETAMRGFGKN-DDGKTK-----CVLEQLLEHNKKVAVTMVMDMLMAGIDTTSSACLTILYHLAR 349

  Fly   352 NPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYR 416
            ||.||.:||.|::::||......|:.:.||:|||||||||..|:..:..||.|...:|.|:|||:
  Fly   350 NPSKQEKLRRELLRILPTTKDSLTDQNTKNMPYLRACIKEGLRITSITPGNFRITPKDLVLSGYQ 414

  Fly   417 VPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSA---GKCPANDLKTKNPFVFLPFGFG 478
            ||.||.|.|..:.....::||.:.:||:|||||:  ||.|   ..|||  .:|:||||:||||||
  Fly   415 VPRGTGVLMGVLELSNDDKYFAQSSEFIPERWLK--SDLAPDIQACPA--ARTRNPFVYLPFGFG 475

  Fly   479 PRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALINLPNIPLKFKFTDV 534
            ||.|:||||.|:|:|....||:|::.|.:...|...:.|.:|..|...::||...|
  Fly   476 PRTCIGKRIAELEIETLLVRLLRSYKVSWLPETPIEYESTIILSPCGDIRFKLEPV 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	191/452 (42%)
Cyp12b2	NP_611370.2	p450	59..511	CDD:299894	193/463 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445017
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	11	10.800