DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and Cyp301a1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_610796.1	Gene:	Cyp301a1 / 36378	FlyBaseID:	FBgn0033753	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	174/546 - (31%)
Similarity:	290/546 - (53%)	Gaps:	43/546 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PIVFSASQQRWQ-----TNVPTA------------EIRNDPEWLQAKPFEEIPKANILSLFAKS- 62
            |.:..|..:|.|     |.|.|.            .|.:..||..|.|:.:||....:.:...:
  Fly    24 PRISGAGSRRAQCRESSTGVATCPHLADSEEASAPRIHSTSEWQNALPYNQIPGPKPIPILGNTW 88

  Fly    63 -ALP-GGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGS 125
             .:| .|:|...::.::...|...||.|:...|::||..|:..::..:.|..:|:||..||||..
  Fly    89 RLMPIIGQYTISDVAKISSLLHDRYGRIVRFGGLIGRPDLLFIYDADEIEKCYRSEGPTPFRPSM 153

  Fly   126 DILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIK 190
            ..|..:::|.|||||..:.|::...|:.|.:|||.|...::|...:|.|.:.:..:.::|:...:
  Fly   154 PSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPVLQLSTIRRYLQPLEVITEDFLVRCE 218

  Fly   191 EIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGK-NSEATKLFKYLDEFFLHSADL 254
            .:.| ..||:|.:|...|::|:||.:..||||.:||.|..:.| :||..::.........:.|.|
  Fly   219 NLLD-ENQELPEDFDNEIHKWSLECIGRVALDTRLGCLESNLKPDSEPQQIIDAAKYALRNVATL 282

  Fly   255 EMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKE---AKEGVVRPEHEQSVLEKLL 316
            |:|...||||.|||..:.::.|:....|.:||:..|.|||:.:   .:.|      |.|::||::
  Fly   283 ELKAPYWRYFPTPLWTRYVKNMNFFVGVCMKYIQSATERLKTQDPSLRAG------EPSLVEKVI 341

  Fly   317 --KVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASM 379
              :.|:|:||:||:|:::.|:||.|....::|..||..|..|.::.||:.::||:.::..|...:
  Fly   342 LSQKDEKIATIMALDLILVGIDTISMAVCSMLYQLATRPVDQQKVHEELKRLLPDPNTPLTIPLL 406

  Fly   380 KNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFL 444
            ..:.:|:..|||..|:|..||||.|.|..||||.||:||.|.......|.:...|||......|.
  Fly   407 DQMHHLKGFIKEVFRMYSTVIGNGRTLMEDSVICGYQVPKGVQAVFPTIVTGNMEEYVTDAATFR 471

  Fly   445 PERWLR-NASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFN 508
            |||||: ....:.||.        :||..||:|:|.|||:|:|..::|:::..|:|:||:.:|:|
  Fly   472 PERWLKPQHGGTPGKL--------HPFASLPYGYGARMCLGRRFADLEMQILLAKLLRNYKLEYN 528

  Fly   509 HSTKNAFRSALINLPNIPLKFKFTDV 534
            |...: :....:..|:.||:||.|.|
  Fly   529 HKPLD-YAVTFMYAPDGPLRFKMTRV 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	154/456 (34%)
Cyp301a1	NP_610796.1	p450	76..530	CDD:299894	153/468 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	10	9.920