DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and Cyp49a1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	183/537 - (34%)
Similarity:	310/537 - (57%)	Gaps:	28/537 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LNILQSQKPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIPKANILSLFAKS---ALPGGKY 69
            ||:  ||:|:...|:.:...:::| ||..:.|. ...:|:.|:|....|.|...|   |...|.|
  Fly    65 LNV--SQQPVTSVATTRTTASSLP-AETTSSPA-AAVRPYSEVPGPYPLPLIGNSWRFAPLIGTY 125

  Fly    70 KNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTV 134
            |..::.::::.|..:||.:..:.|::|...|:...:..:...:|:.|...|.||....||:::..
  Fly   126 KISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGD 190

  Fly   135 YRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQE 199
            .|:|||..|.|:|...|..|..||..|..:|:||:..:.|...::.:..||:..|:.:|| ...|
  Fly   191 LRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRD-EKDE 254

  Fly   200 VPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYF 264
            :|.|||..:.:|.||||..|:||.:||.|...| :.||.::.:.::.||....:||::..|||.:
  Fly   255 LPANFLHELYKWALESVGRVSLDTRLGCLSPEG-SEEAQQIIEAINTFFWAVPELELRMPLWRIY 318

  Fly   265 KTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKV--DKKVATVMA 327
            .|...:..::.:|....:.:|.:.:.:::.:.:...|:.:.|.:.|::|::::.  ::|:|.::|
  Fly   319 PTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA 383

  Fly   328 MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKES 392
            :|:.:.||||||...::.:..|||||:||.:|.:|:.||.|:::::..:..::.:||||||:||:
  Fly   384 LDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKET 448

  Fly   393 QRVYPLVIGNARGLTRDSVISGYRVPAGT-------IVSMIPINSLYSEEYFPKPTEFLPERWLR 450
            .|:.|:||.|.|.|..|:||:||.||.||       :||..|       .|||:|..|||||||:
  Fly   449 LRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDP-------AYFPEPKRFLPERWLK 506

  Fly   451 NASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAF 515
            .::|:|| ||..:.|. :|||.||||||.|||||:|..|:||....|::.|.:.|.:| |.:..:
  Fly   507 QSTDAAG-CPHANQKI-HPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN-SGEFVY 568

  Fly   516 RSALINLPNIPLKFKFT 532
            |.....:|..||.||.|
  Fly   569 RVNSTYIPQSPLNFKLT 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	161/458 (35%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	164/472 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	11	10.820