DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and npp-24

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001379685.1	Gene:	npp-24 / 3564830	WormBaseID:	WBGene00022672	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	453	Identity:	86/453 - (18%)
Similarity:	147/453 - (32%)	Gaps:	153/453 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSD 126
            |....|....:..:|.:|.|..|..::.:          :.|.||       |...|:....|..
Worm   227 SCFKEGYAPRIHRIEPVDGLPCDPLDLRY----------IQTTNP-------RICSVFVLVSGGG 274

  Fly   127 ILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPK---------------------- 169
            :|. |..|:..:|               |:||.:|...|..|.
Worm   275 VLS-HLVVFPNEF---------------GEFRFLVKDQLRLPSSNGDPRIVQNQIRSLKVSRYEI 323

  Fly   170 ---------NVRLYFKKMSQVNQ----EFVELIKEIRDASTQEVPGNFLETINRWT----LESVS 217
                     |:..:|:.::.::.    |....:.|:.||   .:|.:.|....:||    |.:||
Worm   324 ATSSSLFSVNIFPWFEALTSISPTSTLEKETRVSELVDA---VIPSDELSNTTKWTGARALRAVS 385

  Fly   218 V-----VALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMD 277
            |     :|.::: .||.||              |..:|...||.|..      .|.....:.|.|
Worm   386 VQLTQSLATEEE-ELLPES--------------ENIMHLVILENKDG------QPAHLFNISTFD 429

  Fly   278 SVQEVTLKYVDEAIERLEKEAKEGVVRP--------EHEQSVLEKLLK--VDKKVATVMAMDMLM 332
            ::.         :.|......::.|.:|        |.:.:.|:.|..  :.:||:...|:|..|
Worm   430 NIW---------STENKTSFGRDSVSQPPMKSTGSLEQQLAALKPLAACVISEKVSCEEAIDAAM 485

  Fly   333 AGVDTT----------SSTFTALLLCLAKNPEKQA----------RLREEV-----MKVLPNKDS 372
            ...|..          |..|..  .|||.:...||          ||.||.     :|:..::..
Worm   486 KFFDAVDERLKKHCEISKLFVE--RCLAVSSSAQALDEKQQSVDQRLIEETNTVEELKIRMHETK 548

  Fly   373 EFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEE 435
            |..|.:.|.:..|...:.|:   .||.....|...|   :..::.....:..::|..:|.|.|
Worm   549 ERMEGARKGINVLFHRVDEN---VPLSDNEIRIFER---LKEHQKMLSDMTKLVPKMTLDSNE 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	82/434 (19%)
npp-24	NP_001379685.1	Nup88	26..>212	CDD:401976
npp-24	NP_001379685.1	Smc	<455..>653	CDD:224117	34/159 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900