Protein Alignment Cyp12a5 and CYP26C1

DIOPT Version :9

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_899230.2
• Gene: CYP26C1 / 340665
• HGNCID: 20577
• Length: 522
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 104/486 - (21%)
• Similarity: 179/486 - (36%)
• Gaps: 150/486 - (30%)

  Fly    82 RQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNE-----GVWP----FRPGSDIL--------R 129
            |:.||. :|...::||. ::.....::...:...|     ..||    ...||..|        |
Human    77 RERYGT-VFKTHLLGRP-VIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHR 139

  Fly   130 YHRTVYRKDF--------FDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFV 186
            ..|.|..:.|        ...:||.:..:.:||   .:...||.:...:..|.|:..:::
Human   140 RRRKVLARVFSRAALERYVPRLQGALRHEVRSW---CAAGGPVSVYDASKALTFRMAARI----- 196

  Fly   187 ELIKEIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHS 251
                                                 .|||..:..:.:...:.|:.|.|
Human   197 -------------------------------------LLGLRLDEAQCATLARTFEQLVE----- 219

  Fly   252 ADLEMKPSLWRYFKTPL------LKKMLRTMDSVQEVTLKYVDEAI-ERL--EKEAKEG-----V 302
                      ..|..||      |:|.:|..|.:.    ::::.|| |:|  :|.|:.|     :
Human   220 ----------NLFSLPLDVPFSGLRKGIRARDQLH----RHLEGAISEKLHEDKAAEPGDALDLI 270

  Fly   303 VRPE----HEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEV 363
            :...    ||.|:.|  ||..       |:::|.|...||:|..|:|:|.|.::|...|::|||:
Human   271 IHSARELGHEPSMQE--LKES-------AVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREEL 326

  Fly   364 MK--------VLPNK-------------DSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLT 407
            :.        ..|..             :.:.:.|::..:.|:...:||..|:.|.|.|..|...
Human   327 VAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTAL 391

  Fly   408 RDSVISGYRVPAGTIVSMIPINSLY--SEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPF 470
            |...:.||::|.|..| |..|...:  :..|...|..|.|||:.....||.|        ..:.|
Human   392 RTFELDGYQIPKGWSV-MYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRG--------ASSRF 447

  Fly   471 VFLPFGFGPRMCVGKRIVEMELELGTARLIR 501
            .::|||.|.|.|:|:.:.:..|:|....|:|
Human   448 HYIPFGGGARSCLGQELAQAVLQLLAVELVR 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	104/486 (21%)
CYP26C1	NP_899230.2	p450	40..504	CDD:299894	104/486 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D574756at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010