Protein Alignment Cyp12a5 and CYP27C1

DIOPT Version :9

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001354431.1
• Gene: CYP27C1 / 339761
• HGNCID: 33480
• Length: 537
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 144/535 - (26%)
• Similarity: 243/535 - (45%)
• Gaps: 102/535 - (19%)

  Fly    39 PEWLQAKPFEEIPK--ANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNII-------FLPGM 94
            |..|.|.|.   |:  ||:...|.:....       .:.|:.....::||.|.       |:..:
Human    63 PRSLAAMPG---PRTLANLAEFFCRDGFS-------RIHEIQQKHTREYGKIFKSHFGPQFVVSI 117

  Fly    95 MGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRS 159
            ..||.:..         |.|.||..|.|...:..|.:|     |......|:|.::|:.|...||
Human   118 ADRDMVAQ---------VLRAEGAAPQRANMESWREYR-----DLRGRATGLISAEGEQWLKMRS 168

  Fly   160 IVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETIN----RWTLESVSVVA 220
            ::...:::||:|.:|   ..:|||...:|||.|....:|...|..:..:|    ::::|.|:.:.
Human   169 VLRQRILKPKDVAIY---SGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATIL 230

  Fly   221 LDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKT------------PLLKK-- 271
            .:.:||.|    :||......:|::.       ||:   ::..|||            |.:.|
Human   231 YESRLGCL----ENSIPQLTVEYIEA-------LEL---MFSMFKTSMYAGAIPRWLRPFIPKPW 281

  Fly   272 --MLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSV---------LEKLLKVDKKVATV 325
              ..|:.|.:.:.:..:||..:..::.:...|       :.|         |.:.|.:.:..|.|
Human   282 REFCRSWDGLFKFSQIHVDNKLRDIQYQMDRG-------RRVSGGLLTYLFLSQALTLQEIYANV 339

  Fly   326 MAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIK 390
              .:||:|||||||.|.:..:..||::||.|..:..|::|.|..:... |.|.:..||.:||.:|
Human   340 --TEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVP-TAADVPKVPLVRALLK 401

  Fly   391 ESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDS 455
            |:.|::|::.||.|....|.||.||.:|.||.:::....:.|.:|.||:..||.||||||.
Human   402 ETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRK---- 462

  Fly   456 AGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSALI 520
                  .||...:.|..:|||.|.|.|:|:||.|:|:.|...:|:::|.::.:..| ||..:...
Human   463 ------GDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQT-NAVHAKTH 520

  Fly   521 NL--PNIPLKFKFTD 533
            .|  |..|:..:|.:
Human   521 GLLTPGGPIHVRFVN 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	134/487 (28%)
CYP27C1	NP_001354431.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.730