DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	125/525 - (23%)
Similarity:	219/525 - (41%)	Gaps:	127/525 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 IRNDPEWLQAKPFEEI--PKANIL----SLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPG 93
            |:..|.|.....|..|  .|.||.    .::.       |||:.:.|..:...|        :|.
  Fly    34 IKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYE-------KYKDTDNMVGVFTTR--------VPQ 83

  Fly    94 MMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFF----DGVQGIIP--SQGK 152
            :     |||.  |:....::          .:|...:|...:| :|.    |.:.|..|  ..|.
  Fly    84 L-----LVMC--PEYIHKIY----------ATDFRSFHNNEWR-NFVNKKTDMILGNNPFVLTGD 130

  Fly   153 SWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINR---WTLE 214
            .|.:.||.:.|.| .|..|:..:.....|.::|||.|:..:..:|.|    .|:.::.   :|.|
  Fly   131 EWKERRSEIMPAL-SPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSE----GLDAMDLSLCYTTE 190

  Fly   215 SVSVVALDKQLGLLRESGKNSEATKLFKYLD-------EFFLHSADLEMKPSLWRYFKTPLLKKM 272
            .||    |..||:..:|..:: .|.|.|.:.       ||..:|....:...:.:::..|...|.
  Fly   191 VVS----DCGLGVSAQSFTDT-PTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKE 250

  Fly   273 LRT--MDSVQE-VTLKYVDEAIERLEKEAKEGVVRPEHEQ-SVLEKLLKVDKKVA------TVMA 327
            ...  :|.::. :||        ||||        ||.:: ..|..:|::.:|..      .:..
  Fly   251 TEVFFLDIIRRCITL--------RLEK--------PEQQRDDFLNYMLQLQEKKGLHTDNILINT 299

  Fly   328 MDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKES 392
            |..::.|.:||:.....::|.|.:|||:|.::|:|:      ..::.|...|..:|:|.|||.|:
  Fly   300 MTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEI------GSADLTFDQMSELPHLDACIYET 358

  Fly   393 QRVY------------PLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSE-EYFPKPTEFL 444
            .|::            |....|..|.|       ..:..|.:|: ||:.:|:.: :|:..|..|.
  Fly   359 LRLFSPQVAARKLVTEPFEFANKNGRT-------VHLKPGDVVT-IPVKALHHDPQYYEDPLTFK 415

  Fly   445 PERWLRNASDSAGKCPANDLKT-KNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFN 508
            |||:|.  |:..|      :|: ::..|:|.||.|||.|.|.|....:|:.....::|||.::.|
  Fly   416 PERFLE--SNGGG------MKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVN 472

  Fly   509 HSTKN 513
            ..|::
  Fly   473 PKTRS 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	113/473 (24%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	123/517 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910