Protein Alignment Cyp12a5 and Cyp18a1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_523403.2
• Gene: Cyp18a1 / 32858
• FlyBaseID: FBgn0010383
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 121/534 - (22%)
• Similarity: 218/534 - (40%)
• Gaps: 153/534 - (28%)

  Fly    40 EWLQAKPFEEIPKANILSLFAKSALPGGKY--------------KNLEMMEMIDALRQDYGNIIF 90
            :|| .:.:.|:.|           ||.|.:              |:...||    |.:.||::
  Fly    41 QWL-VRNYRELRK-----------LPPGPWGLPVIGYLLFMGSEKHTRFME----LAKQYGSL-- 87

  Fly    91 LPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDG------VQ----- 144
               ...|.|..:|....|::::                   |..:|::.|.|      :|
  Fly    88 ---FSTRLGSQLTVVMSDYKMI-------------------RECFRREEFTGRPDTPFMQTLNGY 130

  Fly   145 GIIPSQGKSWGDFRSIVNPVLMQ-----PKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNF 204
            |||.|.||.|.|.|..::..|.|     ..|.:...:|  ::..|..|.|..:..:..|.|
  Fly   131 GIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQK--RIMTEVHEFIGHLHASDGQPV---- 189

  Fly   205 LETINRWTLESVSVVALDKQLGLLRESGK---NSEATKLFKYLDE----FF--LHSAD----LEM 256
                   .:..|..||:...:..|..|.:   :....:.|.:|.|    .|  :|:.|    ::.
  Fly   190 -------DMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQC 247

  Fly   257 KPSL-------------WRYFKTPLLKKMLRTMD--SVQEVTLKYVDEAIERLEKEAKEGVV--R 304
            .||:             .:.|...::....|:.|  :::::...|:.| ||:.:.|..:..:  .
  Fly   248 FPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCE-IEKAKAEGTDAELFDG 311

  Fly   305 PEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKV--- 366
            ..||:.:::.::            |:..||::|..:|...:.:.:.:||::..|:::|:.:|
  Fly   312 KNHEEQLVQVII------------DLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGR 364

  Fly   367 --LPNKDSEFTEASMKNVPYLRACIKESQRVYPLV-IGNARGLTRDSVISGYRVPAGTIVSMIP- 427
              ||      |...::.:|...:.|.||.|...:| :......|||..::||.:|||:.|  ||
  Fly   365 HRLP------TIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHV--IPL 421

  Fly   428 INSLYSE-EYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEME 491
            |||::.: ..:.||.||.|.|::    |:.|       |.:.|..|:|||.|.|||:|..:..||
  Fly   422 INSVHMDPNLWEKPEEFRPSRFI----DTEG-------KVRKPEYFIPFGVGRRMCLGDVLARME 475

  Fly   492 LELGTARLIRNFNV 505
            |.|..|..:..|::
  Fly   476 LFLFFASFMHCFDI 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	110/478 (23%)
Cyp18a1	NP_523403.2	CYP306A1-like	85..515	CDD:410745	109/474 (23%)