DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and Cyp27a1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_849178.2	Gene:	Cyp27a1 / 301517	RGDID:	727915	Length:	533	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	133/451 - (29%)
Similarity:	219/451 - (48%)	Gaps:	69/451 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLY 174
            |.|.|.||.:|.|...:..:.||     |......||..:||:.|...|..:|..:::|....||
  Rat   117 EQVMRQEGKYPIRDSMEQWKEHR-----DHKGLSYGIFITQGQQWYHLRHSLNQRMLKPAEAALY 176

  Fly   175 FKKMSQVNQEFVELIKEIR--DASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEA 237
            ...:::|..:|:..:.::|  .||..:|| :....:....||::..:..:|::|.|..|.....|
  Rat   177 TDALNEVISDFIARLDQVRTESASGDQVP-DVAHLLYHLALEAICYILFEKRVGCLEPSIPEDTA 240

  Fly   238 TKLFKYLDEFFLHSADLEMKPSLWRYF----KTPLL---KKMLRTMDSVQEVTLKYVDEAIERLE 295
            |         |:.|..|..|.|::..|    ..|||   |:.:...|::.....|.:.:.::.:|
  Rat   241 T---------FIRSVGLMFKNSVYVTFLPKWSRPLLPFWKRYMNNWDNIFSFGEKMIHQKVQEIE 296

  Fly   296 KEAK----EGVVRPEHEQSVLEK-LLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEK 355
            .:.:    :||....:...:|.| ||...:.|.|.  .::::|||||||:|.|..|..|:||||.
  Rat   297 AQLQAAGPDGVQVSGYLHFLLTKELLSPQETVGTF--PELILAGVDTTSNTLTWALYHLSKNPEI 359

  Fly   356 QARLREEVMKVLP------NKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLT-RDSVIS 413
            |..|.:||..|:|      |||       ..::|.|:|.|||:.|:||:|..|:|.:| :::.|:
  Rat   360 QEALHKEVTGVVPFGKVPQNKD-------FAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEIN 417

  Fly   414 GYRVPAGT-------IVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFV 471
            |:..|..|       :||..|       ..||:|..|.|.||||...|       ::...::||.
  Rat   418 GFLFPKNTQFVLCHYVVSRDP-------SVFPEPESFQPHRWLRKRED-------DNSGIQHPFG 468

  Fly   472 FLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFN---HSTKNAFRSALINLPNIPLKF 529
            .:|||:|.|.|:|:||.|:|::|..:|||:.:.|..:   ...|:..|..|:....:.|:|
  Rat   469 SVPFGYGVRSCLGRRIAELEMQLLLSRLIQKYEVVLSPGMGEVKSVSRIVLVPSKKVSLRF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	133/451 (29%)
Cyp27a1	NP_849178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58
		cytochrome_P450	91..527	CDD:425388	131/447 (29%)
		Sterol-binding. /evidence=ECO:0000255	386..400		7/13 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780