DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a5 and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	135/538 - (25%)
Similarity:	241/538 - (44%)	Gaps:	67/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QSQKPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIP-------KANILSLFAKSALPGGKY 69
            |..:.:...||..|....||...:..|.|   .:....:|       ..::|.:|.|..|.
  Rat    23 QPPRSVTSKASASRAPKEVPLCPLMTDGE---TRNVTSLPGPTNWPLLGSLLEIFWKGGLK---- 80

  Fly    70 KNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTV 134
               :..:.:....:.||.|..:  .:|....|...:|...|.::|.|...|.|     |......
  Rat    81 ---KQHDTLAEYHKKYGQIFRM--KLGSFDSVHLGSPSLLEALYRTESAHPQR-----LEIKPWK 135

  Fly   135 YRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQE 199
            ..:|..:...|::..:|:.|...||.....||:|..:....||:::|..:|:|.:.|:.| ....
  Rat   136 AYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCD-ERGR 199

  Fly   200 VPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYF 264
            :|..:.| :|:|:.||:.:|..:|:.|||::..:....|.:          :|...|..:..:..
  Rat   200 IPDLYSE-LNKWSFESICLVLYEKRFGLLQKETEEEALTFI----------TAIKTMMSTFGKMM 253

  Fly   265 KTPL-LKKMLRT---------MDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVD 319
            .||: |.|.|.|         .|::.:.....:|..::|..::.....:...::|..|      .
  Rat   254 VTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHL------S 312

  Fly   320 KKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPY 384
            ||.......::.:|.|:||:::...:|..|::||:.|.||.:||..|||:..:...| .::|:||
  Rat   313 KKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAE-DLRNMPY 376

  Fly   385 LRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWL 449
            |:||:|||.|:.|.|....|.|.:.:|:..|.:|.||::::.......||:.|....:|.|||||
  Rat   377 LKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWL 441

  Fly   450 RNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNV--EFNHSTK 512
            :..            |..|||..||||.|.|||:|:|:.|::|.|....:|:.:::  ..|...:
  Rat   442 QKE------------KKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE 494

  Fly   513 NAFRSALINLPNIPLKFK 530
            ......|:....:|:.|:
  Rat   495 MLHLGILVPSRELPIAFR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	122/462 (26%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	120/455 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.770