DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a5 and Cyp12d1-p

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	222/492 - (45%)
Similarity:	326/492 - (66%)	Gaps:	14/492 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KPFEEIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDF 109
            |.::|||:.|... |.::.:|||:::|..:.|...|:|:.||:|..:|||.||...|.|.|.||.
  Fly    40 KTYDEIPRPNKFK-FMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKDI 103

  Fly   110 EVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLY 174
            |:||||||:||.|.|.|.:.|.|...|.|.:..|||::.||.::||..||.:||:.|||:.:|:|
  Fly   104 EMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIFMQPRGLRMY 168

  Fly   175 FKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATK 239
            ::.:|.:|.||:|.||||||..|.|||.:|.:.|:|...||:.:||.|:|:||:|::..||:|..
  Fly   169 YEPLSNINNEFIERIKEIRDPKTLEVPEDFTDEISRLVFESLGLVAFDRQMGLIRKNRDNSDALT 233

  Fly   240 LFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVR 304
            ||:...:.|..:..|:::||:|:...||..:||.||::....|..|.:.|..:.|||..:.|  .
  Fly   234 LFQTSRDIFRLTFKLDIQPSMWKIISTPTYRKMKRTLNDSLNVAQKMLKENQDALEKRRQAG--E 296

  Fly   305 PEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPN 369
            ..:..|:||:|:::|.|||.:|::|:|.||||.|::..:|:||||:|:|:|||:||||::.::|.
  Fly   297 KINSNSMLERLMEIDPKVAVIMSLDILFAGVDATATLLSAVLLCLSKHPDKQAKLREELLSIMPT 361

  Fly   370 KDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSE 434
            |||...|.:||::|||||.|||:.|.||..:|..|....|.::||||||.||.| ::..|.|..|
  Fly   362 KDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMRTCQNDVILSGYRVPKGTTV-LLGSNVLMKE 425

  Fly   435 -EYFPKPTEFLPERWLRNASDSAGKCPANDLKTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTA 497
             .|:|:|.|||||||||:        |....|.: :||.|||||||||||:|||:|::|:|...|
  Fly   426 ATYYPRPDEFLPERWLRD--------PETGKKMQVSPFTFLPFGFGPRMCIGKRVVDLEMETTVA 482

  Fly   498 RLIRNFNVEFNHSTKNAFRSALINLPNIPLKFKFTDV 534
            :|||||:||||......|::..:..|.|...|||||:
  Fly   483 KLIRNFHVEFNRDASRPFKTMFVMEPAITFPFKFTDI 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	206/451 (46%)
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	205/448 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445012
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S4770
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	11	10.850