Protein Alignment Cyp12a5 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 106/522 - (20%)
• Similarity: 212/522 - (40%)
• Gaps: 107/522 - (20%)

  Fly    39 PEWLQAKP--FEEIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNI--IFLPG-----M 94
            |..:::.|  |..||.......|.||.:           |.::...:.||.:  ..:.|     :
Human    61 PAGVKSPPYIFSPIPFLGHAIAFGKSPI-----------EFLENAYEKYGPVFSFTMVGKTFTYL 114

  Fly    95 MGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRS 159
            :|.|...:..|.|:.::  ..|.|:.        |....|:.|    ||...:|
Human   115 LGSDAAALLFNSKNEDL--NAEDVYS--------RLTTPVFGK----GVAYDVP----------- 154

  Fly   160 IVNPVLMQPK-------NVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLESVS 217
              |||.::.|       |:..:.:.:|.:.:|    .||..::..:....|..|.::...:.:.|
Human   155 --NPVFLEQKKMLKSGLNIAHFKQHVSIIEKE----TKEYFESWGESGEKNVFEALSELIILTAS 213

  Fly   218 VVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEV 282
            .....|::    .|..|.:..:|:..||..|.|:|.|     |..:...|..::..|....::::
Human   214 HCLHGKEI----RSQLNEKVAQLYADLDGGFSHAAWL-----LPGWLPLPSFRRRDRAHREIKDI 269

  Fly   283 TLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLK-----VDKKVATVMAMDMLMAGVDTTSSTF 342
            ..|.:.:  .|..:|..:.::     |::|:...|     .|.:||. |.:.:|:||..|:|:|.
Human   270 FYKAIQK--RRQSQEKIDDIL-----QTLLDATYKDGRPLTDDEVAG-MLIGLLLAGQHTSSTTS 326

  Fly   343 TALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLT 407
            ..:...||::...|.:...|...|........|...:|::..|..||||:.|:.|.::...|...
Human   327 AWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMAR 391

  Fly   408 RDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVF 472
            ....::||.:|.|..|.:.|..:...::.:.:..:|.|:|:|::...|..|           |.:
Human   392 TPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEK-----------FAY 445

  Fly   473 LPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF--------NHSTKNAFRSALINLPNIP-LK 528
            :|||.|...|:|:....::::...:.::|.:..:.        |::|       :|:.|..| ::
Human   446 VPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTT-------MIHTPENPVIR 503

  Fly   529 FK 530
            :|
Human   504 YK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	96/473 (20%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	96/476 (20%)