Protein Alignment Cyp12a5 and CYP27B1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 131/495 - (26%)
• Similarity: 221/495 - (44%)
• Gaps: 91/495 - (18%)

  Fly    49 EIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMT---HNPKDFE 110
            :||..:..|..|:....||..:..|:        |..|...|.|..:...|.|.|   ..|...|
Human    39 DIPGPSTPSFLAELFCKGGLSRLHEL--------QVQGAAHFGPVWLASFGTVRTVYVAAPALVE 95

  Fly   111 VVFRNEGVWP----FRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNV 171
            .:.|.||..|    |.|.::    ||...::     ..|::.::|:.|...||::.|:|::|:..
Human    96 ELLRQEGPRPERCSFSPWTE----HRRCRQR-----ACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151

  Fly   172 RLYFKKMSQVNQEFVELIKEIRDAST------QEVPGNFLETINRWTLESVSVVALDKQLGLL-- 228
            ..|...::.|..:.|..::..|...|      ::|.|.|.    ::.||.::.|.|..:||.|
Human   152 ARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFY----KFGLEGIAAVLLGSRLGCLEA 212

  Fly   229 ----------RESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPLLKKMLRTMDSVQEVT 283
                      |..|....:|.|...:..:..|     :.|..|        .::.|..|.:
Human   213 QVPPDTETFIRAVGSVFVSTLLTMAMPHWLRH-----LVPGPW--------GRLCRDWDQM---- 260

  Fly   284 LKYVDEAIERLEKEA--KEGVVRPEHEQSVLEK-------LLKVDKKVATVM--AMDMLMAGVDT 337
            ..:....:||.|.||  :.| .:||.:   ||.       |.:.:....:::  ..::|:|||||
Human   261 FAFAQRHVERREAEAAMRNG-GQPEKD---LESGAHLTHFLFREELPAQSILGNVTELLLAGVDT 321

  Fly   338 TSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEAS-MKNVPYLRACIKESQRVYPLVIG 401
            .|:|.:..|..|:::||.|..|..|:...|....|.:..|: :..:|.|:|.:||..|:||:|.|
Human   322 VSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPG 386

  Fly   402 NARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKT 466
            |:|...:|..:..|.:|..|:|::....:......||:|..|.|.|||       |:.|     |
Human   387 NSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL-------GEGP-----T 439

  Fly   467 KNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVE 506
            .:||..||||||.|.|:|:|:.|:||::..|:::.:|.|:
Human   440 PHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQ 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	124/462 (27%)
CYP27B1	NP_000776.1	CYP27B1	68..503	CDD:410741	123/458 (27%)