Protein Alignment Cyp12a5 and CYP24A1

DIOPT Version :9

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 126/459 - (27%)
• Similarity: 219/459 - (47%)
• Gaps: 54/459 - (11%)

  Fly    85 YGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPS 149
            ||.|..:  .:|....|...:|...|.::|.|..:|.|......:.:|. |||:.:    |::..
Human    93 YGKIFRM--KLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRD-YRKEGY----GLLIL 150

  Fly   150 QGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLE 214
            :|:.|...||.....||:|..|.....|:::|..:|:..|.|:.| ....|...:.| :|:|:.|
Human   151 EGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCD-ERGHVEDLYSE-LNKWSFE 213

  Fly   215 SVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTPL-LKKMLRT--- 275
            |:.:|..:|:.|||:::. ..||....         .|...|..:..|...||: |.|.|.|
Human   214 SICLVLYEKRFGLLQKNA-GDEAVNFI---------MAIKTMMSTFGRMMVTPVELHKSLNTKVW 268

  Fly   276 ------MDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAG 334
                  .|::.:.....:|..:|:..::.....:...:.|:      ::.||.......::.:|.
Human   269 QDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQN------RLSKKELYAAVTELQLAA 327

  Fly   335 VDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLV 399
            |:||:::...:|..|::||:.|.:|.:|:..|||.......| .::|:|||:||:|||.|:.|.|
Human   328 VETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE-DLRNMPYLKACLKESMRLTPSV 391

  Fly   400 IGNARGLTRDSVISGYRVPAGTIVSMIPINSL-YSEEYFPKPTEFLPERWLRNASDSAGKCPAND 463
            ....|.|.:.:|:..|.:|.||:: |:....| .||:.|...::|.|||||:.
Human   392 PFTTRTLDKATVLGEYALPKGTVL-MLNTQVLGSSEDNFEDSSQFRPERWLQE------------ 443

  Fly   464 LKTK-NPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF--NHSTKNAFRSALINLPNI 525
             |.| |||..||||.|.|||:|:|:.|::|.|....::|.::::.  |...:......|:....:
Human   444 -KEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSREL 507

  Fly   526 PLKF 529
            |:.|
Human   508 PIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	126/459 (27%)
CYP24A1	NP_000773.2	p450	59..512	CDD:278495	126/459 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	1	0.900	-	-		OOG6_100895
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770