Protein Alignment Cyp12a5 and CYP11B1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 123/490 - (25%)
• Similarity: 217/490 - (44%)
• Gaps: 81/490 - (16%)

  Fly    46 PFEEIPK------ANILSLFAKSALPGGKYKNLEM------MEMIDALRQDYGNIIFLPGMMGRD 98
            |||.:|:      ..:|.::.:..     |::|.:      .|:....|.|          :|..
Human    37 PFEAMPRRPGNRWLRLLQIWREQG-----YEDLHLEVHQTFQELGPIFRYD----------LGGA 86

  Fly    99 GLVMTHNPKDFEVVFRNEGVWPFRPGSD---ILRYHRTVYRKDFFDGVQ-GIIPSQGKSWGDFRS 159
            |:|....|:|.|.:.:.:.:.|.|...:   ..|.||         |.: |:....|..|...|.
Human    87 GMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR---------GHKCGVFLLNGPEWRFNRL 142

  Fly   160 IVNPVLMQPKNVRLYFKKMSQVNQEFVELIKE-----IRDASTQEVPGNFLETINRWTLESVSVV 219
            .:||.::.|..|:.:...:..|.::|.:.:|:     .|.:.|.:|.    .:|..:|:|:.::.
Human   143 RLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQ----PSIFHYTIEASNLA 203

  Fly   220 ALDKQLGLLRESGKNSEATKLFKYLDEFFLHSADLEMKP-SLWRYFKTPLLKKMLRTMDSVQEVT 283
            ...::|||:..| .:|.:......|:..|..:..|...| ||.|:....:.|:.....|.:
Human   204 LFGERLGLVGHS-PSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI---- 263

  Fly   284 LKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLL---KVDKKVATVMAMDMLMAGVDTTSSTFTAL 345
            .:|.|..|:::.:|.  ...||:...|::.:||   ::........:|::....||||.......
Human   264 FQYGDNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326

  Fly   346 LLCLAKNPEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDS 410
            |..||:||..|..||:|.:....: .||..:.:...:|.|||.:||:.|:||:.:...|..:.|.
Human   327 LFELARNPNVQQALRQESLAAAAS-ISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDL 390

  Fly   411 VISGYRVPAGTIVSMIPINSLYS----EEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFV 471
            |:..|.:||||:|.:.    |||    ...||:|..:.|:|||    |..|        :...|.
Human   391 VLQNYHIPAGTLVRVF----LYSLGRNPALFPRPERYNPQRWL----DIRG--------SGRNFY 439

  Fly   472 FLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVE 506
            .:|||||.|.|:|:|:.|.|:.|....::::..||
Human   440 HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	115/442 (26%)
CYP11B1	NP_000488.3	CYP11B	72..499	CDD:410737	116/450 (26%)