Protein Alignment Cyp12a5 and CYP2E1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000764.1
• Gene: CYP2E1 / 1571
• HGNCID: 2631
• Length: 493
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 131/514 - (25%)
• Similarity: 212/514 - (41%)
• Gaps: 96/514 - (18%)

  Fly    64 LPGGKYK-----NLEMMEM------IDALRQDYGNIIFLPGMMGRDGLVMTHNPK-------DFE 110
            ||.|.:.     ||..:|:      ...|.|.:|.:..|  .:|...:|:.|..|       |::
Human    32 LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTL--YVGSQRMVVMHGYKAVKEALLDYK 94

  Fly   111 VVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYF 175
            ..|...|        |:..:|.   .:|     :|||.:.|.:|.|.|......|   :|..:..
Human    95 DEFSGRG--------DLPAFHA---HRD-----RGIIFNNGPTWKDIRRFSLTTL---RNYGMGK 140

  Fly   176 K-KMSQVNQEFVELIKEIRDASTQEVPGNFLETINRWTLESVSVVALDKQLGLLRESGKNSEATK 239
            : ..|::.:|...|::.:|....|.....||  |.......::.:...|.
Human   141 QGNESRIQREAHFLLEALRKTQGQPFDPTFL--IGCAPCNVIADILFRKH--------------- 188

  Fly   240 LFKYLDEFFL-------HSADLEMKPSLWRYFKTPLL--------KKMLRTMDSVQEVTLKYVDE 289
             |.|.||.||       .:..|...|.|..|...|..        :|:::.:..|:|...:.|.|
Human   189 -FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKE 252

  Fly   290 AIERLEKEAKEG-----VVRPEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCL 349
            ..:.|:......     :|..|.|:...|:|..:|.  .||...|:..||.:|||:|....||.|
Human   253 HHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG--ITVTVADLFFAGTETTSTTLRYGLLIL 315

  Fly   350 AKNPEKQARLREEVMKVL-PNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGN-ARGLTRDSVI 412
            .|.||.:.:|.||:.:|: |::.....:  .:.:||:.|.:.|.||...||..| ....|||::.
Human   316 MKYPEIEEKLHEEIDRVIGPSRIPAIKD--RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIF 378

  Fly   413 SGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGF 477
            .||.:|.||:|.....:.||..:.||.|.:|.||.:|    :..||...:|       .|.||..
Human   379 RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL----NENGKFKYSD-------YFKPFST 432

  Fly   478 GPRMCVGKRIVEMELELGTARLIRNFNVEFNHSTKNAFRSAL-INLPNIPLKFKFTDVP 535
            |.|:|.|:.:..|||.|....::::||::.....|:...|.: |....||.::|...:|
Human   433 GKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	122/476 (26%)
CYP2E1	NP_000764.1	CYP2C-like	64..487	CDD:410758	121/476 (25%)