DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12a5 and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus

Alignment Length:	544	Identity:	136/544 - (25%)
Similarity:	232/544 - (42%)	Gaps:	87/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QKPIVFSASQQRWQTNVPTAEIRNDPEWLQAKPFEEIPK------ANILSLFAKSALPGGKYKNL 72
            |.|::.:.......|:.|             :.|.|||.      .|:...:.:|......|..:
Mouse    25 QGPVLSTGKGAGTSTSSP-------------RSFNEIPSPGDNGWLNLYHFWRESGTQKIHYHQM 76

  Fly    73 EMMEMIDALRQDYGNIIFLPGMMGRDGL-----VMTHNPKDFEVVFRNEGVWPFR----PGSDIL 128
            :..       |.||.|.       |:.|     |...:|||..::|..||..|.|    |.   :
Mouse    77 QSF-------QKYGPIY-------REKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPW---V 124

  Fly   129 RYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELI-KEI 192
            .||:      ::....|::.....:|...|.::|..:|.|..::.:...:..|.|:|:::: :.|
Mouse   125 AYHQ------YYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRRI 183

  Fly   193 RDASTQEVPGNFLETIN----RWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSAD 253
            :    |:..|||...|:    |::.||:|.|...:::|:|.|. .:.||.:....:.:.|..|..
Mouse   184 K----QQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEI-VDPEAQRFINAVYQMFHTSVP 243

  Fly   254 -LEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQ--SVLEKL 315
             |.:.|..:|..:|...|......|    |.....||..:....:.::   :.:..|  .||..|
Mouse   244 MLNLPPDFFRLLRTKTWKDHAAAWD----VIFNKADEYTQNFYWDLRQ---KRDFSQYPGVLYSL 301

  Fly   316 L---KVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKDSEFTEA 377
            |   |:..|.......:||..||||||.|....|..:|.|.:.|..||.||:........:..:
Mouse   302 LGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAK- 365

  Fly   378 SMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTE 442
            .::.||.|:|.|||:.|::|:.:...|....|.|:..|::||.|:|.:..........:||.|.:
Mouse   366 MVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNK 430

  Fly   443 FLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEF 507
            |.|.|||..:.::            ..|.:|.||:|.|.|:|:||.|:|:.:....|:.||.:|.
Mouse   431 FDPTRWLEKSQNT------------THFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFRIEV 483

  Fly   508 NHSTKNAFRSALINLPNIPLKFKF 531
            .:......:.:||.:|..|:.|.|
Mouse   484 QNLRDVGTKFSLILMPENPILFNF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	124/469 (26%)
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		4/31 (13%)
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	128/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870