DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12a5 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_650782.1	Gene:	Cyp12a5 / 42293	FlyBaseID:	FBgn0038680	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_446215.1	Gene:	Cyp27b1 / 114700	RGDID:	69192	Length:	501	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	132/475 - (27%)
Similarity:	216/475 - (45%)	Gaps:	45/475 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KPFEEIPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDGLVMTHNPKDF 109
            :...:||..:..|..|:....|| ...|..:::..|.|  ||.|  ..|..|....|...:|...
  Rat    28 RSLSDIPGPSTPSFLAELFCKGG-LSRLHELQVHGAAR--YGPI--WSGSFGTLRTVYVADPALV 87

  Fly   110 EVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLY 174
            |.:.|.|...|.|........||..:::     ..|::.:.|:.|...||::.|:|::|:....|
  Rat    88 EQLLRQESHCPERCSFSSWSEHRRRHQR-----ACGLLTADGEEWQRLRSLLAPLLLRPQAAAGY 147

  Fly   175 FKKMSQVNQEFVELIKEIRDAST------QEVPGNFLETINRWTLESVSVVALDKQLGLLRESGK 233
            ...:..|..:.|..::..|...:      .:|.|.|.    ::.||.:..|.|..:||.| |:..
  Rat   148 AGTLDSVVSDLVRRLRRQRGRGSGLPDLVLDVAGEFY----KFGLEGIGAVLLGSRLGCL-EAEV 207

  Fly   234 NSEATKLFKYLDEFFLHSADLEMKPSLWRYFKTP-LLKKMLRTMDSVQEVTLKYVD----EAIER 293
            ..:.....:.:...|: |..|.|....|.:...| ...::.|..|.:.....|:|:    ||..|
  Rat   208 PPDTETFIEAVGSVFV-STLLTMAMPSWLHRLIPGPWARLCRDWDQMFAFAQKHVEQREGEAAVR 271

  Fly   294 LEKEAKEGVVRPEHEQSVL--EKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQ 356
            .:.:.:|.:....|....|  || :.|...|..|  .::|:|||||.|:|.:..|..|:::||.|
  Rat   272 NQGKPEEDLPTGHHLTHFLFREK-VSVQSIVGNV--TELLLAGVDTVSNTLSWALYELSRHPEVQ 333

  Fly   357 ARLREEVM-KVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGNARGLTRDSVISGYRVPAG 420
            :.|..|:. .|.|...:.....::..:|.|:|.|||..|:||:|.||:|...||..:..|.:|..
  Rat   334 SALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGNYVIPQD 398

  Fly   421 TIVSMIPINSLYSEEYFPKPTEFLPERWLRNASDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGK 485
            |:||:....:......|.:|..|.|.|||       |:.||     .:||..||||||.|.|:|:
  Rat   399 TLVSLCHYATSRDPAQFREPNSFNPARWL-------GEGPA-----PHPFASLPFGFGKRSCIGR 451

  Fly   486 RIVEMELELGTARLIRNFNV 505
            |:.|:||::..|:::.:|.|
  Rat   452 RLAELELQMALAQILTHFEV 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	p450	81..531	CDD:278495	124/439 (28%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	125/441 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880