Protein Alignment Cyp12a5 and cyp24a1

DIOPT Version :10

• Sequence 1: NP_650782.1
• Gene: Cyp12a5 / 42293
• FlyBaseID: FBgn0038680
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: XP_012808417.2
• Gene: cyp24a1 / 100497429
• XenbaseID: XB-GENE-479201
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 529
• Identity: 136/529 - (25%)
• Similarity: 247/529 - (46%)
• Gaps: 71/529 - (13%)

  Fly    27 QTNVPTA----EIRND--------PEWLQAKPF-EEIP-KANILSLFAKSALPGGKYKNLEMMEM 77
            |.::|||    :::.:        |..|.|.|. .::| ..::|.:..|..|.       ...|.
 Frog    22 QHSIPTATAVCDLKEEELPAPSSCPHSLAALPGPTKLPILGSLLDILRKGGLK-------RQHEA 79

  Fly    78 IDALRQDYGNIIFLPGMMGRDGLVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDG 142
            :.:..:.:|.|..:  .:|....|....|...|.::|.|..:|.|     |........:|:.|.
 Frog    80 LASYHKQFGKIFRM--KLGSFDSVHIGAPCLLEALYREESNYPKR-----LEIKPWKAYRDYRDE 137

  Fly   143 VQGIIPSQGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFVELIKEI--RDASTQEVPGNFL 205
            ..|::..:||.|...||.....||:|..|.....|:::|..:|::.|..:  .|.:.:::   :.
 Frog   138 AYGLLILEGKDWQRVRSAFQQKLMKPTEVGKLDTKINEVLVDFMKRIDSVCDEDGTIEDL---YC 199

  Fly   206 ETINRWTLESVSVVALDKQLGLLRES-GKNSE--ATKLFKYLDEF-FLHSADLEMKPSLWRYFKT 266
            | :|:|:|||:.:|..:|:.|.|:.: |:.::  .|.:...:..| .:....:|:..||    .|
 Frog   200 E-LNKWSLESICLVLYEKRFGFLQPNLGEEAQNFITAIKMMMSTFGLMMVTPVELHKSL----NT 259

  Fly   267 PLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGVVRPEHEQSVLEKLLKVDKKVATVMAMDML 331
            .:.|......||:.:....::|..:.:|..:..|..:...:..|      |:.||.......:||
 Frog   260 KIWKDHTHAWDSIFKTAKCHIDRRLTKLSSKGSEDFLCTIYNDS------KLSKKEMYATITEML 318

  Fly   332 MAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKV-LPNKDSEFTEASMKNVPYLRACIKESQRV 395
            :..|:||:::....:..:::||..|.:|.||:..| ||  |...|...::|:|||:||:|||.|:
 Frog   319 IGAVETTANSLLWAIFNISRNPHIQKKLLEEIESVLLP--DQVPTADDIRNMPYLKACLKESMRI 381

  Fly   396 YPLVIGNARGLTRDSVISGYRVPAGTIVSMIPINSLY---SEEYFPKPTEFLPERWLRNASDSAG 457
            .|.:....|.|.:::|:..|.:|.||:::   |||..   ::|.|....:|.|||||:..:
 Frog   382 TPSIPFTTRTLDKETVLGDYVLPKGTVLT---INSHVLGSNQECFDNWNQFRPERWLQQKN---- 439

  Fly   458 KCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNV--EFNHSTKNAFRSALI 520
                    |.|||..:|||.|.|||:|:|:.|::|:|....|||.:.:  ..|...:......|:
 Frog   440 --------TINPFAHVPFGIGKRMCIGRRLAELQLQLTLCWLIRKYEIVATDNDPVETLHLGTLM 496

  Fly   521 NLPNIPLKF 529
            ....:|:.|
 Frog   497 PSRELPVAF 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12a5	NP_650782.1	CYP24A1-like	82..528	CDD:410677	122/457 (27%)
cyp24a1	XP_012808417.2	CYP24A1	84..502	CDD:410738	121/455 (27%)