DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6040 and Peak1

DIOPT Version :9

Sequence 1:	NP_650781.2	Gene:	CG6040 / 42292	FlyBaseID:	FBgn0038679	Length:	1784	Species:	Drosophila melanogaster
Sequence 2:	NP_001101619.1	Gene:	Peak1 / 315686	RGDID:	1312026	Length:	1733	Species:	Rattus norvegicus

Alignment Length:	2173	Identity:	384/2173 - (17%)
Similarity:	664/2173 - (30%)	Gaps:	849/2173 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SICSHFTQNAWKKDLCSNCFKSK-------DEHKAAAAAAASKMGGGH----------------- 44
            |.|:.||::.||...|.||||.|       |..||.....:.|....|
  Rat     2 SACNTFTEHVWKPGECKNCFKPKSLHQLPPDSEKAPITHGSVKTNANHSNNHRVRNTGNFRPPVA 66

  Fly    45 -KPDKEVK---------------------TDYP-----NKHKTP--------------------- 61
             ||...||                     .:.|     |:::|.
  Rat    67 KKPTIAVKPTMMVADGQSVCGELSIQEHCENKPVILGWNQNRTSLSQKPLNNNSEGDTEGFGSVP 131

  Fly    62 --------AKSI---------IKKAFG------VR------------------------------ 73
                    ||:|         :|:..|      ||
  Rat   132 QQCANNDRAKTIPNNNGLTEVLKEIAGLDASPPVRGNETNSRETFLGRINDCYKRSLERKIPPSC 196

  Fly    74 LTGTSSSSSGSG---NGSGKSVNSKGVKVCFPKQLHEIIGYGGEWSEDDDDDDDHDFMNLGNEHD 135
            :||::..|.|..   :||.:.::::|.:.|:|           |:|..::.::|..|.|:..||:
  Rat   197 MTGSTKDSQGKHVILSGSTEVISNEGGRFCYP-----------EFSSGEESEEDVLFSNMEEEHE 250

  Fly   136 DMAISETDDE--------------------------------------ETKELKRITRANTDFNM 162
            ..  .|:|:|                                      ..|.|:||  ...|::.
  Rat   251 SW--DESDEELLAMEIRMRGQPRFANFRANTLSPVRFFVSKKWNTIPLRNKSLQRI--CAVDYDD 311

  Fly   163 NNGNLLGDAEENIKKSFAALKLGAPQVDKEGKKQTLTINVMPFGQPMGKSAPAPAKTASAESKST 227
            :...:|...|||...|:.           :|..|:          .:...:.:|..:.:.||:|.
  Rat   312 SYDEILNGYEENSGVSYG-----------QGSIQS----------TVSSDSTSPDSSFTEESRSE 355

  Fly   228 AAKSVASSLAGATPAKAKPATITTATAIKSSSTTTAIASVTKKVTTTLTPTLTMAKS--TTPSAT 290
            .|.|::..:.....:...|.........:|:|.:....:..|..:.|       :||  ..|...
  Rat   356 TASSLSQKICNGGISPGNPGNSKDMAETESNSESPPPNNEEKDSSLT-------SKSPVKVPETH 413

  Fly   291 GAAAATATQSRDGKDSPPIERAMEKSLLDEISETL--------EQKQKLSETNAS---------- 337
            .|..|...|.:|||.:...|:...|:..|...:.:        ||.:.....|..
  Rat   414 KAVLALRLQEKDGKIAVQTEKPENKASTDIAGQAVTISLVPVEEQTKPYRVVNLEQPLCKPYTVV 478

  Fly   338 DASSGGSGSNI-------STSASNS------------NSH--NSSKIKF-ELSALSDSPK---PF 377
            |.|:..:..::       |:|..||            |:|  .||.|:: |:...|.||:   |.
  Rat   479 DVSAAMASEHLGRPKVKGSSSTPNSPVTSPALTPGQINAHLKKSSAIRYQEVWTSSTSPRQKIPK 543

  Fly   378 LDLKK-PIARNAPITRDQAKPKVNVCHKYSDTDSNCSDTENGVSAYYDVVETQLSYENLPDGKYS 441
            ::|.. ....|.|       |:.| |||.:.|    |.|...:|                    |
  Rat   544 IELSTGGTGPNVP-------PRKN-CHKSAPT----SPTATNIS--------------------S 576

  Fly   442 EQVGVATAAQTDSSSNSHYSSSQYITDMLLSSKTRAA--SYNLHEGNFMTSKITSDGLIVTKCSS 504
            :.:.|.:...::...||:.::......:::..:...|  |.|..:...:.:....|.|.:.|
  Rat   577 KTIPVKSPNLSEIKFNSYNNAGMPPFPIIIHDEPSYARSSKNAIKVPIVINPNAYDNLAIYK--- 638

  Fly   505 DDALDSTGSSFDGSSDE-----------ENAYNMIRSESDSGIGISLGSEYKNLGLAKGTAASGE 558
                     ||.|:|.|           .:.|..|  |::|.:..|..|:..:...|||.::|.|
  Rat   639 ---------SFLGTSGELSVKEKTTSVISHTYEEI--ETESKVSDSTPSKLADGPPAKGFSSSAE 692

  Fly   559 -KRQLLAEK---------------KLSASTNNSDYEDIQIGDQAVPKPAVKSRELHGEPDGSADP 607
             ||..:|:|               :.|.|:.:|....||   :...:|..|:.    ...||..|
  Rat   693 RKRGSVAQKVQEFNNCLNRGQSSPQRSYSSTHSSPAKIQ---RPTQEPVGKTE----SAQGSQVP 750

  Fly   608 DNSLEQKQK------QTVEK-EAEQQLPALPKSPPPPMKIDARPSFLHGLKKPELPVKPLVNSHP 665
            .:|...::|      |.|.. :..|..|..|:|.|....:|            ||...|     |
  Rat   751 GSSGSTREKASAVLCQIVASIQPPQTPPEAPQSSPKACSVD------------ELYAIP-----P 798

  Fly   666 SSNATSNGSQLKSFLGKRQPSCAEQQFISQLQSAISKSTECLQLAKENLAADEAKLKKGKAPNPP 730
            .::.|.|       :.|..|...:..|.||...                        :|:|....
  Rat   799 DADTTKN-------IPKNTPVRPKSLFTSQSSG------------------------EGEAHQTT 832

  Fly   731 PEPKLSAPPTPERDYSLVVEFEQATKAAAKPAEKATSSGPSETSSSSSSTESQATATGAPAGTAG 795
            ..|                    .||....|:.|..:|.||:.   .:||:|:......|..:..
  Rat   833 ESP--------------------TTKTQKDPSTKPVTSPPSKL---VTSTQSEPPPPFPPPRSTS 874

  Fly   796 AATVAAASATNNSSLYTRKPALPVAA--AAPVIREKDKRERAVINPK----FRSLNTFVMQRTNA 854
            :...|:.....:.:.:| ||..|..:  |..::..:..|..|...||    |:|.  |..::|:.
  Rat   875 SPYHASNLLQRHFTNWT-KPTSPTRSTEAESILHSEGSRRAADAKPKRWISFKSF--FRRRKTDE 936

  Fly   855 AKQMQLQSASSVL-----SLKQPMTPEPTPRNQRHLSMSEECLAAAGLDKKSPS------ASPPQ 908
            .::.:.:.....|     ::...:.|.|.   |||...:|    |.|...:.|:      ..|.|
  Rat   937 EEEKEKEREKGKLVGLDGTVIHMLPPPPV---QRHHWFTE----AKGESSEKPAIVFMYRCDPDQ 994

  Fly   909 KQKSKFSIKKFLRMGTNGGKSGESLAKRESSVYTEICTGTEEGNASGKPRLVIIHPIDINPTAVE 973
            ...|....|    .|.:.|::.:.|.:           ..||...|        ||    |:.:.
  Rat   995 GHLSVDQSK----AGADNGRTEDVLLR-----------NLEEKKNS--------HP----PSQIP 1032

  Fly   974 VVKDITKTSDSVSAQTVAVVTAKPPAPPLRSSASEGQRAHEANKPARPPPPKSAELRRKQKTELT 1038
                 .|....|:.:....::.:.|..|  :...:|...    .|..|||    :|.|:::.:
  Rat  1033 -----DKACSRVTHEVAEELSPRDPRTP--AVKQDGTSV----TPTLPPP----DLEREEEKD-- 1080

  Fly  1039 ATLSASSVDSSVLPLATGSGSVKLKADNVYANLGEIRSSIAPRKPERTASMREREAQLELVRKRG 1103
                |:|..:.|.|.:.           .|:|||:.|:::.|.|..|              ..:|
  Rat  1081 ----ATSDPTDVSPCSA-----------TYSNLGQSRAAMIPPKHPR--------------HPKG 1116

  Fly  1104 VLTDTISICSSNGDNVATDQGKTMGKTNANSSSSGQEAGKSASTANSRTSTFERIP---QKKSEP 1165
            .|.|.|:.    |:           ||:....::.|...........|.:| |.||   ||..|.
  Rat  1117 ALDDAIAF----GE-----------KTDQEVLNASQPTPPPLPKKMIRANT-EPIPKDLQKSMES 1165

  Fly  1166 KMSISSKLEIFEQRSMDAADAAQRSSLKDSVRKINSTIDSYLK--DKRDYENMYEFVKMGSPTPP 1228
            .:.:.:........:.||:.|             .|::...||  |...||::...:....|.|.
  Rat  1166 SLCVVANPTYDIDPNWDASSA-------------GSSVSYELKGLDVESYESLERPLHKERPVPS 1217

  Fly  1229 AANGNTTPTPSTSTPPPPPTRSNIDLSVAGQRLTQATRRNNIYSDTASIASYSRSEYGPVRNYGL 1293
            .||                                         ..:|:|:.|..:       ..
  Rat  1218 TAN-----------------------------------------SISSLATLSIKD-------RF 1234

  Fly  1294 NNSLANIPRIISASYAGSEVGEFDIYAPYSYYGSEAGGDVATDINDSVWGMPQANKNRSKATNRL 1358
            :||:.::                         .|..|                           |
  Rat  1235 SNSMESL-------------------------SSRRG---------------------------L 1247

  Fly  1359 RMRKGRSVVHKTIEDNYTAVVVANHEALAQVLDQLQQTPVVPAALRPLANAINLRYEDFTILEGT 1423
            ..|:.||:..            ...:||.:.||..::
  Rat  1248 SCRQARSIQK------------PQRQALYRGLDSREE---------------------------- 1272

  Fly  1424 QAFVVGK-KAFHAALWSSSPVTLALSADCNQLGGVAGELSQLSGGV---------SDVLNPVTEF 1478
               |||| ::.|      :.....|:..|..| .:||:..||..||         ||  .|..|.
  Rat  1273 ---VVGKLRSLH------TDALKRLAVKCEDL-FMAGQKDQLRFGVDSWSDFRLTSD--KPCCEA 1325

  Fly  1479 CDLV---PSYQLPLMPSTEVTLLQATISVLPRLQLETLQSIGSILKGKSQVLDKSNFN------- 1533
            .|.|   .||....:.:..|.:.::...       |:.|...|:...:|..:   :||
  Rat  1326 GDAVYYTASYAKDPLSNYAVKICKSKAK-------ESQQYYHSLAVRQSLPV---HFNIQQDCGH 1380

  Fly  1534 FRGSIPNL----------SGLKDGNGLIAGNLRNVVSVQNLSTLNEESSANSMGAE--------- 1579
            |...:||.          ...:|||......::...|..|....:|..|:.....:
  Rat  1381 FLAEVPNRLLPWEDPNAPEKAEDGNEDSEEEVKAETSGGNPEPCSESESSQKENQQVTNRKQRSH 1445

  Fly  1580 ------------------DGSTNANAMPAFDDVMTREVAFIMLQLVNGMKNLQAKAIEETPLSLS 1626
                              |...:....|   |:..|:|..::|||.:|:::|:...:....|.|.
  Rat  1446 VVVITREVPHLTVADFVRDSLAHHGKSP---DLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLE 1507

  Fly  1627 NVVLSKDMDNKDAQ--------------ARLCV------LQGNNNDDDEPMGTLCKCAHSALT-- 1669
            |::|.:.......|              .||.|      .|.::..|.:.:....:.|...:|
  Rat  1508 NLLLVQHQPGGATQCPSPADPCPTSACPTRLIVSNFSQAKQKSHLMDPQILRDQSRLAPEIITAT 1572

  Fly  1670 ---------------DML---------PATK---------------------ITPILADILQQER 1689
                           :||         |..|                     :..:.:.:|....
  Rat  1573 QYKKCDEFQTGILIYEMLHLPNPFDENPELKEKEYTRTDLPRIPLRSPYSWGLQQLASCLLNPNP 1637

  Fly  1690 AES--LSKAKAVLEFVLWGPSD---VALTGSAK--ERELDLQRWLDLERATVLHGLVRTRVE--- 1744
            :|.  :|.||.:|:.:||||.:   ...|.||.  ::...||.|||::|..::.......::
  Rat  1638 SERILISDAKGILQCLLWGPREDLFQIFTTSATLVQKNALLQNWLDIKRTLLMIKFAEKSLDREG 1702

  Fly  1745 -LTVYDECHLMFLVRSTAKMMNDAAKIV 1771
             :::.|.....:|..:|...::...||:
  Rat  1703 GISLEDWLCAQYLAFATTDSLSYIVKIL 1730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6040	NP_650781.2	None
Peak1	NP_001101619.1	Herpes_BLLF1	<474..851	CDD:282904	96/497 (19%)
Peak1	NP_001101619.1	PKc_like	<1490..1655	CDD:419665	24/164 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4307
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050