DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6040 and Prag1

DIOPT Version :9

Sequence 1:	NP_650781.2	Gene:	CG6040 / 42292	FlyBaseID:	FBgn0038679	Length:	1784	Species:	Drosophila melanogaster
Sequence 2:	NP_001100785.1	Gene:	Prag1 / 306506	RGDID:	1311793	Length:	1368	Species:	Rattus norvegicus

Alignment Length:	1866	Identity:	334/1866 - (17%)
Similarity:	541/1866 - (28%)	Gaps:	658/1866 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SICSHFTQNAWKKDLCSNCFKSKDEHKAAAAAAASKMGGGHKPDKEVKTDYPNKHKTPAKSII-- 66
            |.||.|.::.||...|.|||..:.:|:..|         ||  .|...:..|...:.||:..|
  Rat     2 SACSDFVEHIWKPGSCKNCFCLRSDHQLTA---------GH--PKARASSLPAGARLPARPEICR 55

  Fly    67 ------------KKAFGVRLTGTSSSSSGSGNGSGKSVNSKGV-------KVCFPKQLHEIIGYG 112
                        |....|:.|..:|.::.....:..|.....|       |:...||....|.|.
  Rat    56 LEDEGVNGLAYSKPTIAVKPTMMTSETADLWTEASLSAEVPKVNWRRTPGKLLLQKQEDGPIVYL 120

  Fly   113 GEWSEDDDDDDDHDFMNLGNEHDDMAISETDDEETKELKRITRANTDFNMNNGNLLGDAEENIKK 177
            |            .|..:......:|.::::       .|...|.|...::|      .|..:.:
  Rat   121 G------------SFRGMQKAAGPLACTDSN-------SRCPPAYTMVGLHN------LEARVDR 160

  Fly   178 SFAALKLGAPQVDKEGKKQTLTINVMPFGQPMGKSAPAPAKTASAESKSTAAKSVASS-LAGATP 241
            : .||:....|.:|.|:::                  .|:...|...|..|...:.|| |.|..|
  Rat   161 N-TALQPVNFQEEKAGREE------------------LPSAQESFRQKLAAFTGMTSSCLKGPRP 206

  Fly   242 AKAKPATITTATAIKSSSTTTAIASVTK---KVTTTLTPTLTMAKSTTPSATGAAAATATQSRDG 303
            . ..|..:..:...:..|......|...   :..:.|        ...|.:..|...|....|..
  Rat   207 C-TSPQPLRESLPSEDDSDQRCSPSGDSEGGEYCSIL--------DCRPESRDAVHNTEGSGRRR 262

  Fly   304 KDSPPIERAMEKSLLDEISETLEQKQKL----------SETNA-----------SDASSGGSGSN 347
            .|..||  ..|:......:|  |:||.|          |..|.           |:|:|...|.:
  Rat   263 GDCSPI--CWEQGTCTRPTE--EEKQALNFPRECCGQGSTANPPHLGPKKPSLNSEAASSSDGLS 323

  Fly   348 ISTSASNSNSHNSSKIKFELSALSDSPKPFLDLKKPIARNAPITRDQAKPKVNVCHKYSDTDSNC 412
            ..:|.|.:||..:..::.:..:|         :|:|.:                   ....||.|
  Rat   324 CGSSRSGANSPFAPHLENDYCSL---------VKEPTS-------------------VKQQDSGC 360

  Fly   413 SDTENG--VSAYYDVVETQLSYENL-PDGKYSEQVGVATAA---QTDSSSNSHYSSSQYITDMLL 471
            ....:|  |....|:....|..|.: |:..|:|......||   |.........||.|..|....
  Rat   361 HLVNSGKYVGQAVDLQPPALPREAVQPEPIYAESAKRKKAAPVPQRPEPKKEQVSSGQVWTGDTW 425

  Fly   472 SSKTRAASYNLHEGNFMTSKITSDGLIVTKCSSDDALDSTGSSFDGSSDEENAYNMIRSESDSGI 536
            |.||.:......||.....::.:...::                 .:..||:...:..|..||.:
  Rat   426 SQKTPSGWSQEREGPNAAPQVATTITVI-----------------AAHPEEDHRTIYLSSPDSAV 473

  Fly   537 GISLGSEYKNLGLAKGTAASGEKRQLLAEKKLSASTNNSDYEDIQIGDQAVPKPAVKSRELHGEP 601
            |:..                                               |:.:: :::|||..
  Rat   474 GVQW-----------------------------------------------PRGSL-NQDLHGSG 490

  Fly   602 DGSADPDNSLEQKQKQTVEKEAEQQLPALPKSPPPPMKIDARPSFLHGLKKPELPVKPLVNSHPS 666
            :                                        .|..:.||...|        |||
  Rat   491 E----------------------------------------EPLVVQGLSSRE--------SHP- 506

  Fly   667 SNATSNGSQLKSFLGKRQPSCAEQQFISQLQSAISKSTECLQLAKENLAADEAKLKKGKAPNPPP 731
            .|.|.|.|       |.:|:         :...:|||:                  .|.:|..|.
  Rat   507 HNMTENSS-------KEKPA---------IPPKLSKSS------------------PGGSPVSPA 537

  Fly   732 EPKLSAPPTPERDYSLVVEFEQATKAAAKPAEKATSSGPSETSSSSSSTESQATATGAPAGTAGA 796
            .|.|:       |:|                 ...:||.|..|..||...:..|::....|.|..
  Rat   538 APPLT-------DHS-----------------DGNTSGSSVGSQPSSRVPTNLTSSCQTNGVAAG 578

  Fly   797 ATVAAASATNNSSLYTRKPALPVAAAAPVIREKDKRE--RAVINPKF-RSLNTFVMQRTNAAKQM 858
            .........|:|.|..|:|.....|.:...|.:::.|  :.:::..: |.|...:...:|::...
  Rat   579 DPAKCPPQANSSVLDQRRPRYQTGAWSRQCRIEEEEEVGQELLSQSWGRELENGIADHSNSSTWH 643

  Fly   859 QL----------------QSASSVLSLKQP--------MTPEPTPRNQRHLSMSEECLAAAGLDK 899
            :|                .|.|:..:.:.|        .:|.|.|...|||....:  :::.|:|
  Rat   644 RLHPIDGASGQNGKTNSGMSKSASFAFEFPKDRGRLESFSPPPPPPKSRHLLKMNK--SSSDLEK 706

  Fly   900 KSPSASPPQKQKSKFSIKKFLRMGTNGGKSGESLAKRESSVYTEICTGTEEGNAS-------GKP 957
            .|.|                         |.|||:......:....||:.:..||       |.|
  Rat   707 VSQS-------------------------SAESLSPSFRGAHVSFTTGSTDSLASDSRTCSDGGP 746

  Fly   958 RLVIIHPIDINPTAVEVVKDITKTSDSVSAQTVAVVTAKPPAP-PLRSSASEGQRAHEANKPARP 1021
            .....|                  |.::|.:       |..|| |..|.::|..   ..:.||:|
  Rat   747 SCEATH------------------SPTISGK-------KLFAPVPFPSGSTEDV---SPSGPAQP 783

  Fly  1022 PP-PKSAELRRKQKTELTATLSASSVDSSVLPLATGSGSVKLKADNVYANLGEIRSSI-APRKPE 1084
            || |:...:.|          :|||.|.    .....||.|.:..:...||....::: |..:|.
  Rat   784 PPLPQKKIVSR----------AASSPDG----FFWTQGSPKPRTASPKLNLSHSETNVCAHDEPP 834

  Fly  1085 RTASMR---------EREAQLELVRKRGV-LTDTISICSSNGDNVATDQGKTMGKTNANSSSSGQ 1139
            .:.|:.         .....||...|..| ....:...:|.|   ........|:...::|||..
  Rat   835 LSYSLNSGNHPHHVFSSSEPLEKAFKGSVPWAPALGPANSKG---GCGSPNLQGRAATSTSSSQL 896

  Fly  1140 EAGKSASTANSRTSTFERIPQKKSEPKMSISSKLEIFEQRSMDAADAAQRSSLKDSVRKINSTID 1204
            .....|||.:|:......:        .|||||     :.:..........||...|.|......
  Rat   897 SVSSQASTGSSQLQLHSLL--------SSISSK-----EGTYAKLGGLYTQSLARLVTKCEDLFM 948

  Fly  1205 SYLK-DKRDYENMYEFVKMGSPTPPAANGNTTPTPSTSTPPPPPTRSNIDLSVAGQRLTQATRRN 1268
            ..|| :.|..||.:...|:....|...:|:.....:|.:..|                      :
  Rat   949 GGLKTELRFDENSWSLFKLICNKPCCDSGDAIYYGATCSKDP----------------------D 991

  Fly  1269 NIYSDTASIASYSRSEYGPVRNYGLNNSLANIPRIISASYAGSEVGEFDIYAPYSYYGSEAGGDV 1333
            :||:                      ..:...|...||||....|       |..:...:..|..
  Rat   992 SIYA----------------------VKICKTPEPKSASYCSPSV-------PVHFNIQQDCGHF 1027

  Fly  1334 ATDINDSVWGMPQ-ANKNRSKATNRLRMRK--------GRSVVHKTIEDNYTAVVVANHEALAQV 1389
            ...:..|:...|. ::|:.:.|.......:        .|.|.|:|..| :....||:|.|..:|
  Rat  1028 VASVPSSMLAFPDTSSKDPAPAAPSHTPAQEQDCVVVITREVPHQTASD-FVRDSVASHRAEPEV 1091

  Fly  1390 LDQLQQTPVVPAALRPLANAINLRYEDFTILEGTQAFVVGKKAFHAALWSSSPVTLALSADCNQL 1454
            .::.     |...|..|.|.:....|                  |..:.....:...|...||
  Rat  1092 YERR-----VCFLLLQLCNGLEHLKE------------------HGIIHRDLCLENLLLVHCN-- 1131

  Fly  1455 GGVAGELSQLSGGVSDVLNP----VTEFCDLVPSYQLPLMPSTEVTLLQATISV--LPRLQLETL 1513
                   .|.|.|.|  .||    .|..|        |.......|..|.....  ||||
  Rat  1132 -------PQSSPGPS--ANPSVPTTTSRC--------PSAAPAATTACQGGPGEKHLPRL----- 1174

  Fly  1514 QSIGSILKGKSQVLDKSNFNFRGSIPNLSGLKDGNGLIAGNLRNVVSVQNLSTLNEESSANSMGA 1578
             .|.:.||.|.                    |.|               ..:.|.::.|...:..
  Rat  1175 -IISNFLKAKQ--------------------KPG---------------GTTNLQQKKSQARLAP 1203

  Fly  1579 EDGSTNANAMPAFDDVMTREVAFIMLQLVNGMKNLQAKAIEETPLSLSNVVLSKDMDNKDAQARL 1643
            |  ..:|:....||:..|..:.:.:|...|             |..:...:..:|.
  Rat  1204 E--IVSASQYRKFDEFQTGILIYELLHQPN-------------PFEVRAQLRERDY--------- 1244

  Fly  1644 CVLQGNNNDDDEPMGTLC-------KCAHSALTDMLPATKITPILADILQQERAESLSKAKAVLE 1701
                  ..:|..|:.||.       :.||..|.            ||.:::.|   :.:||.||:
  Rat  1245 ------RREDLPPLPTLSLYSPGLQQLAHLLLE------------ADPIKRIR---IGEAKRVLQ 1288

  Fly  1702 FVLWGPSDVALTGSAKEREL---DLQRWLDLERATVLHGLVRTRVE 1744
            .:||||....:.......|:   .|..|:|::||.::.......||
  Rat  1289 CLLWGPRRELVEQPCPSEEVLCNTLHNWIDMKRALMMMKFAEKAVE 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6040	NP_650781.2	None
Prag1	NP_001100785.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..236		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..330		7/32 (22%)
		PHA03307	377..>607	CDD:223039	65/401 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..443		13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..605		36/172 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..792		40/210 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..818		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..901		6/30 (20%)
		Required for homodimerization. /evidence=ECO:0000269\|PubMed:29503074	906..949		10/55 (18%)
		PKc_like	<1012..1292	CDD:419665	72/415 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1134..1166		10/41 (24%)
		Required for homodimerization. /evidence=ECO:0000269\|PubMed:29503074	1293..1368		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4307
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050