DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and PTK2

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_012593.3	Gene:	PTK2 / 853522	SGDID:	S000003820	Length:	818	Species:	Saccharomyces cerevisiae

Alignment Length:	750	Identity:	149/750 - (19%)
Similarity:	233/750 - (31%)	Gaps:	275/750 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 YSV---DDFV----KEKIGSGFFSEVYKV--THRTTGQVMVLKMNQLRANRPNML-----REVQL 156
            |||   |:||    .:.||||..|||.||  ::|......:.|:|.:....|...     :|..:
Yeast   244 YSVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFII 308

  Fly   157 LNKLSH----ANILSFMGVCVQEGQLHALTEYINGG----------SLEQLLAN---KEVVLSAT 204
            ...|||    .|....:.|        ..|.|...|          .|.||:..   |.|..:
Yeast   309 AKHLSHNVHITNTFYLLKV--------PTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFN-- 363

  Fly   205 QKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLA---------NDQYEAVVGDFGLAAKIPV 260
            :|..|...:|:|:.:.||.||.||||..:||||....         :|.|..:..|:    ..||
Yeast   364 EKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDY----TSPV 424

  Fly   261 KSRKSRLETVGSPYWVSPECLKGQWYDQ---------------TSDVFSFGIIQCEIIARIEADP 310
            |:.:.   .:|||.:..||.:   ::|.               ..|.::.||:...:|..|
Yeast   425 KTCQG---MIGSPPYTPPEVM---YFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNI---- 479

  Fly   311 DMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYD---AKSRPTFHDATKKLTLLLEKYEH 372
                         :.|::.|..|.     |...:...||   ....|.|.|          |..|
Yeast   480 -------------IPFIDSCNTDA-----RFREFEVSYDNFINHQNPHFRD----------KGCH 516

  Fly   373 ESSAGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDGFRFP 437
            :...|:.       .:.:....:::...:..|.:.|..||..|.              :|.|..|
Yeast   517 KPGPGSE-------YSLARNFKNTDATRIAWRLADPNPATRYTM--------------DDLFNDP 560

  Fly   438 SKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFP-----MHT 497
            ..:.....:  .||.       ||.:....:|::|.         ....|||.:..|     :||
Yeast   561 FFQQIETCV--EPND-------DDLVRVPELRKSTS---------TNDFSENSLDAPHDQEVIHT 607

  Fly   498 SPSDKARCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQYKPTS 562
            |                                                            .|..
Yeast   608 S------------------------------------------------------------NPFL 612

  Fly   563 EKDHNGSKPNPFEALAQ---LRGVKKILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAG 624
            :|:...|||.....:|:   |:...|:.| :.||....|||
Yeast   613 KKETLTSKPRSMLEIAESPSLKQKSKVKD-SAKTKTHDVGD------------------------ 652

  Fly   625 AQGGGTST-------------------------EETSTGNKASAATPSEPKSLPVSPHMTRKYSA 664
             :||..||                         ||.:|.|..|......|.|..|..:::...|.
Yeast   653 -EGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEATTTNVDSILEKPTPTSTKVEDNLSEDDST 716

  Fly   665 I-ELRLPQRISNAAPPAVT-SAPPPSIALPTDEDD--CDDCNSEGEDPDGGGNCADAESSSDDSA 725
            : ||:   .:.|:.|...| :.|.|..|....:.|  ..|.:.:.|.|....|.:....||..::
Yeast   717 MKELK---SMLNSTPTTPTHNGPTPLPAKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNS 778

  Fly   726 VRPSTVPTARKYRANSLYAHPLFRGSNGTSMKSTS 760
            :|....|:....:...:..|.|...::.|:|.|.|
Yeast   779 LRSLGSPSVSSSKKKKVIHHHLDITNSVTNMSSVS 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	69/300 (23%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	69/304 (23%)
PTK2	NP_012593.3	S_TKc	259..562	CDD:214567	80/375 (21%)
PTK2	NP_012593.3	STKc_HAL4_like	261..562	CDD:270896	80/373 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	69	1.000	Inparanoid score	I1703
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050