DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and limk1a

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001036156.1	Gene:	limk1a / 735292	ZFINID:	ZDB-GENE-061212-3	Length:	648	Species:	Danio rerio

Alignment Length:	487	Identity:	151/487 - (31%)
Similarity:	221/487 - (45%)	Gaps:	117/487 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLNQHSGPG--PPSEICGLSVDQVDSSAASPFIWPSTAGMCTTATTVTTSTN-GDATAE---AP 59
            :|::|.|.|.  .|.....:.|.||.....||              .|..|.: ||...|   .|
Zfish   179 VSIDQASSPNGYSPEHKRTVRVSQVYPDCISP--------------DVKNSIHVGDRILEINGTP 229

  Fly    60 VKHQPLH-------------------------------NGGWIGNGLPPAPVTRTISSD------ 87
            :::.||.                               :||...:| .|:|:||..|.|
Zfish   230 IQNVPLDEIDLLIQETSRLLQLTIEHDPHDQGPSVDHVDGGPSPSG-GPSPITRPPSQDISNLRS 293

  Fly    88 RLVTGS--------------------------SCRALRTAVSALYSVDDFVK-EKIGSGFFSEVY 125
            |::|.|                          |.|.:......::...|.:. |.:|:|.|.:..
Zfish   294 RIITRSYSIDKSPSSSSAPSPLSLRKDIGRSESLRGVSNRTHRIFRASDLIHGEVLGTGCFGQAI 358

  Fly   126 KVTHRTTGQVMVLKMNQL----RANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYIN 186
            |||||.||:|||:|  :|    ...:...|:||:::..|.|.|:|.|:||..::.:|:.:.|||.
Zfish   359 KVTHRETGEVMVMK--ELIRFDEETQRTFLKEVKVMRCLDHPNVLKFIGVLYKDKRLNFIAEYIK 421

  Fly   187 GGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGD 251
            ||:|..::.|.:......|::..|..||.||:|:|...|.||||.|.|.|:|    :....||.|
Zfish   422 GGTLRDIIKNMDSNYPWGQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVR----ENKSVVVAD 482

  Fly   252 FGLAAKIPVK---------SRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIE 307
            ||| :::.|:         .|:.|...||:|||::||.:.|:.||:..|:|||||:.||||.|:.
Zfish   483 FGL-SRLMVEDRSVERRKADRRKRYTVVGNPYWMAPEMIHGKSYDEKVDLFSFGIMLCEIIGRVN 546

  Fly   308 ADPDMMPRTASFGLDYLAFV-ELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYE 371
            ||||.:||...|||:...|: |.||.|.|..|..:|..||..||:.||.|    .||...||..:
Zfish   547 ADPDYLPRALDFGLNTAVFLEEHCPADCPAAFFPIAALCCDLDAEKRPAF----TKLESWLEDLK 607

  Fly   372 HESSAGASPLSSLELI-------NCSPGGSDS 396
            .....|...:|.|||:       :.|.||.:|
Zfish   608 MHLELGLHLVSELELLHQDFMQKHTSGGGKNS 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	105/264 (40%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	108/267 (40%)
limk1a	NP_001036156.1	LIM1_LIMK1	5..79	CDD:188846
		LIM	86..140	CDD:295319
		PDZ	164..254	CDD:278991	18/88 (20%)
		TyrKc	346..603	CDD:197581	107/267 (40%)
		STKc_LIMK1	349..610	CDD:271123	108/271 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920