DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and TESK1

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_006276.2	Gene:	TESK1 / 7016	HGNCID:	11731	Length:	626	Species:	Homo sapiens

Alignment Length:	739	Identity:	258/739 - (34%)
Similarity:	341/739 - (46%)	Gaps:	192/739 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GDATAEAPVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDF-VKEK 115
            |:...|.|  ..|...||..|.|.|                ||.||||:|||:|..|||| ..||
Human    16 GEVPGEGP--PGPGGTGGGPGRGRP----------------SSYRALRSAVSSLARVDDFHCAEK 62

  Fly   116 IGSGFFSEVYKVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHA 180
            ||:|||||||||.||.:|||||||||:|.:||.|.||||||:|:|.|.|||.||||||.:|||||
Human    63 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHA 127

  Fly   181 LTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQ- 244
            ||||:|||:|||||::.| .||...::.|||.||||:.|:|..|:|||||||||.|:|.  .|:
Human   128 LTEYMNGGTLEQLLSSPE-PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRR--EDRG 189

  Fly   245 YEAVVGDFGLAAKIPV---KSRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARI 306
            :.|||||||||.||||   .:||..|..||||||::||.|:|:.||:.:|||:|||:.||:|||:
Human   190 FTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARV 254

  Fly   307 EADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYE 371
            .||||.:|||..||||..||..|...|.|..||.||.:||..:..:|..|.:.|:.|..:||:..
Human   255 PADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319

  Fly   372 HESSAGASPLSSLELI----NCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDED 432
            .     .:||:...|.    :.:.||         |.|::|..           .|| |.....|
Human   320 E-----PAPLTRTALTHNQGSVARGG---------PSATLPRP-----------DPR-LSRSRSD 358

  Fly   433 GFRFPSKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENII------ 491
            .|..||.:|       .||.....:..:...|:..:|....||       ..:.|:.::
Human   359 LFLPPSPES-------PPNWGDNLTRVNPFSLREDLRGGKIKL-------LDTPSKPVLPLVPPS 409

  Fly   492 -----HFPMHTSP-------SDKARCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPV 544
                 ..|:.|:|       :...||      ||...||..||::.      |::|.|.|
Human   410 PFPSTQLPLVTTPETLVQPGTPARRC------RSLPSSPELPRRME------TALPGPGP----- 457

  Fly   545 PAVLTLRKVGDPQYKPTSEKDHNGSKPNPFEALAQLRGVKKILDANPKTYAAGVGDLFSSCFEML 609
            |||       .|..:...|.:.:..:|.|.....||            ..|....:..|:|
Human   458 PAV-------GPSAEEKMECEGSSPEPEPPGPAPQL------------PLAVATDNFISTC---- 499

  Fly   610 APFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATPSEPKSLPVSPHMTRKYSAIELRLPQ--- 671
                                           :||:.|..|:|.||   :.....|:.:..||
Human   500 -------------------------------SSASQPWSPRSGPV---LNNNPPAVVVNSPQGWA 530

  Fly   672 -----RISNAAPPAVT-----SAPPPSIALPTDEDDCDDCNSEGEDPDGGGNCADAESSSDDSAV 726
                 |..::.|.|..     .:||||  .|.:.|:...|          ..|.....|....::
Human   531 GEPWNRAQHSLPRAAALERTEPSPPPS--APREPDEGLPC----------PGCCLGPFSFGFLSM 583

  Fly   727 RPSTVPTARKYR-----ANSLYAH 745
            .|...|...:||     |.||..|
Human   584 CPRPTPAVARYRNLNCEAGSLLCH 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	152/253 (60%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	153/257 (60%)
TESK1	NP_006276.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		10/42 (24%)
		TyrKc	61..311	CDD:197581	152/252 (60%)
		PKc_TESK	63..318	CDD:271057	153/257 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..373		15/69 (22%)
		Required for interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q63572	419..524		34/178 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..488		21/100 (21%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q63572	527..626		21/93 (23%)
		Required for interaction with PARVA. /evidence=ECO:0000250\|UniProtKB:Q63572	527..624		21/93 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..564		8/36 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1493
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm42019
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.880