DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and tesk2

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001103946.1	Gene:	tesk2 / 568213	ZFINID:	ZDB-GENE-070209-68	Length:	634	Species:	Danio rerio

Alignment Length:	766	Identity:	264/766 - (34%)
Similarity:	352/766 - (45%)	Gaps:	215/766 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 PVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVKEKIGSGFFSE 123
            |.:...|.:||        ...|.::..|| |..||.|||.:|.|.|..:|||:.|.||||||||
Zfish    16 PDRLDDLDSGG--------GAETSSLPLDR-VCPSSYRALISAFSCLTRLDDFICEWIGSGFFSE 71

  Fly   124 VYKVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGG 188
            ||||.||.:.|||.||||:|.:||.||||||||:|:|||.|||.|||||||||||||||||||||
Zfish    72 VYKVRHRASDQVMALKMNKLSSNRANMLREVQLMNRLSHPNILRFMGVCVQEGQLHALTEYINGG 136

  Fly   189 SLEQLL-ANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDF 252
            :||||| :||  .||...:::|||.||.|:||:|..|||||||||||.||::..|. |.|:||||
Zfish   137 NLEQLLDSNK--FLSWATRVKLALEIAMGLSYLHSKGIFHRDLTSKNCLIKSDENG-YTAIVGDF 198

  Fly   253 GLAAKIPVKSRK-SRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRT 316
            |||.|||....: .:|..||||:|::||.|:.:.|::.:||||:|||.|||||||:||||.:|||
Zfish   199 GLAEKIPSHDYEGEKLSVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRT 263

  Fly   317 ASFGLDYLAFVEL---CPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESSAGA 378
            .:|||||.||..:   ||.|    ||:|||.||..|.|.||:|.|..|:|..:.:|.:.|.
Zfish   264 ENFGLDYHAFQHMVGDCPAD----FLQLAFNCCNMDPKLRPSFPDIVKRLEEIQKKLKAEE---- 320

  Fly   379 SPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDGFRFPSKKSAS 443
                           |:.|.:.||               ||.:..:.:.       :.|.:|...
Zfish   321 ---------------SERERMLLT---------------AGEVEKKPIP-------KGPGEKGIK 348

  Fly   444 AALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSPSDKARCHQM 508
            ...|         .||.|..:..:..|.           ||::                    .:
Zfish   349 RLNP---------LGFQDDKIPPKSPRP-----------RRNI--------------------WL 373

  Fly   509 QRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQYKPTSEK-DHNGSKPN 572
            .|.:|...:..|.|:::                           |.||.|.|.... .|...|.|
Zfish   374 SRSQSDIFARKPARKVN---------------------------VQDPYYNPEPRGFIHGLPKVN 411

  Fly   573 PFEALAQLRGVK-KILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGGGTSTEETS 636
            ||.|...|:|.| |..|...|:       :||..|::.:|.                |:.:.:..
Zfish   412 PFSAREDLKGGKIKFYDMPSKS-------VFSLMFDLHSPH----------------GSQSSQQP 453

  Fly   637 TGNKASAATPSEP--------KSLPVSPHMTRKYSAIELRLPQRISNAAPP-------------- 679
            ..|.:.|....||        :||||||.:... ..:....|...|.||.|
Zfish   454 QPNISGANNWPEPWQLPGRQCRSLPVSPQLPHS-EVLFSSHPASRSEAAQPNGESRQRTLNSWAK 517

  Fly   680 --AVTSAPP--P--------------SIALPTD--EDDCDDCNSE----GEDPD------GGGNC 714
              .||..||  |              |..:|:|  |.:..||:|.    .:|.|      ..|.|
Zfish   518 KFTVTEIPPYKPRADREEEVEATEDWSSLIPSDGGETEAMDCSSSRGSPADDKDTTLNQMHNGFC 582

  Fly   715 ADAESSSDDSAV--RPSTVPTARKYRANSLYAHPLFRGSNGTSMKSTSTGE 763
            .|.|:...|..:  ..:::..:.......|....|      |:.|::|:||
Zfish   583 EDMEAEDQDGVLVTNKNSLTLSMSVEPQELCPIVL------TACKASSSGE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	160/254 (63%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	160/258 (62%)
tesk2	NP_001103946.1	PKc_TESK	64..316	CDD:271057	160/258 (62%)
tesk2	NP_001103946.1	TyrKc	64..309	CDD:197581	159/251 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1368
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm25715
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5384
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.910