DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and tesk1a

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	XP_021332499.1	Gene:	tesk1a / 556048	ZFINID:	ZDB-GENE-090312-74	Length:	657	Species:	Danio rerio

Alignment Length:	756	Identity:	265/756 - (35%)
Similarity:	354/756 - (46%)	Gaps:	152/756 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 NGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVKEKIGSGFFSEVYKVTHRTTGQVMV 137
            |..|..|....:.....:..||.||||:|||:|..:|||..|||||||||||:||.||.|||||.
Zfish     6 NQEPCEPPLHALYGPNRIRPSSYRALRSAVSSLARIDDFFCEKIGSGFFSEVFKVQHRITGQVMA 70

  Fly   138 LKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVLS 202
            ||||.|.:|:.||||||||:|:|.|.|||.|:||||.||||||||||||||:||||| :.::.||
Zfish    71 LKMNTLASNKANMLREVQLMNRLCHPNILRFLGVCVHEGQLHALTEYINGGNLEQLL-DSDIYLS 134

  Fly   203 ATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDFGLAAKIPVKS---RK 264
            .|.:|.|:|.||||:.|:|..|||||||||||.|:| ..|..:.|||||||||.|||..|   .|
Zfish   135 WTVRIGLSLDIARGLQYLHSKGIFHRDLTSKNCLVR-CENGAFTAVVGDFGLAEKIPDYSDGVEK 198

  Fly   265 SRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVEL 329
            ..|..||||||::||.|:|:.|::..|||::|||.||||||||||||::|||..||||...|..:
Zfish   199 QPLAVVGSPYWMAPEMLRGELYNEKVDVFAYGIILCEIIARIEADPDILPRTEDFGLDVDTFEHM 263

  Fly   330 CPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESSAGASPLSSLELI------- 387
            .. |.||.||::|..||..:|.|||.|    .::.::||:.|.|......|: .||.|
Zfish   264 VG-DCPPSFLQMAVDCCNMNADSRPAF----SEIVVMLERIERERVKSEIPV-ILEPIAIDVSPY 322

  Fly   388 --NCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDG-----FRFPSKK--SAS 443
              ..||.....:.::.:....:|...:.|......:.|..|:: |.:|     |..|||.  |.:
Zfish   323 RRRSSPCHPCDQRLSRSQSDMLPPATSPCLGTPARVNPFSLRQ-DLNGGRIKLFDTPSKSVISLT 386

  Fly   444 AALPGTPNGSA-----GSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSPSDKA 503
            ..||..|:.||     ||.|......:.|....|.:|..::              |......::.
Zfish   387 FTLPPPPDPSASPPLSGSPGLRGPPRRCRSLPCTPELGRQL--------------PFRDQEVEED 437

  Fly   504 RCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVL-----TLRKVGDPQYKPTSE 563
            |..::.::       |..::|...|   .::.|.       ..||     :|.:|.:.:.....|
Zfish   438 RSEELGQE-------TKDKELEGQQ---DAVEDS-------GLVLDLDMVSLERVEEEEEDEEVE 485

  Fly   564 KDHNGSKPNPFEALAQLRGVKKILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGG 628
            |: ..|...|.:.           .::|.|....|                     ..|....|.
Zfish   486 KE-GQSLTEPMDC-----------SSSPDTTEGNV---------------------SGKRLISGS 517

  Fly   629 GTSTEETSTGNKASAATP--SEPKSLPVSPHMTRKYSAIELRLP---QRISNAAPPAVTSAPPPS 688
            ..|:...|.|    .|||  :.|..||..|.:......:....|   .|::....||....|
Zfish   518 SYSSSLQSNG----WATPISNGPPLLPPLPRLDNNNGVLRPGRPFAWVRLNGYRGPAPEPLP--- 575

  Fly   689 IALPTDEDDCDDCNSEGEDPDGGGNCADAESSSDDSAVR---PS-TVPTARKYRANSLYAHPLFR 749
               ||::||...|.:          |..|..|.....:|   || ..|..|.||.        |.
Zfish   576 ---PTEQDDVISCPA----------CCLAGFSFPSLCLRGAPPSRRGPPRRPYRT--------FN 619

  Fly   750 GSNGTSMKSTSTGEFESPTLLKASASTITLTASVGATNSCE 790
            |  |.:..:|:.|      ||...|     |....:|.|||
Zfish   620 G--GDASTATAKG------LLCRGA-----TGLAPSTASCE 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	155/252 (62%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	155/256 (61%)
tesk1a	XP_021332499.1	PKc_TESK	49..303	CDD:271057	156/260 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1368
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm25715
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920