DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and slpr

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	1354	Identity:	270/1354 - (19%)
Similarity:	459/1354 - (33%)	Gaps:	384/1354 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNQHSGPGPPSEICGLSVDQVDSSAASPFIWPSTAGMCTTATTVTTSTNGDATAEAPVKHQPLHN 67
            |.|...|..| ||....::||::......:|.:............|...|:.........:...:
  Fly    19 LEQLHHPQIP-EIPIPDLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGD 82

  Fly    68 GGW----IGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSAL------YSVDDFVKEKIGSGFFS 122
            .||    ||:.:...|.......|.|....|     :|:..:      |:..| :||.||||.|.
  Fly    83 VGWWTGKIGDKVGVFPKDFVTDEDPLQLNVS-----SAIGDIQPHEIEYNELD-IKEVIGSGGFC 141

  Fly   123 EVY-----------KVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEG 176
            :|:           |:.|: ||:      :.::..|.|:|:|.:|...|.|.||.:..|||:..
  Fly   142 KVHRGYYDGEEVAIKIAHQ-TGE------DDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNT- 198

  Fly   177 QLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHD---AGIFHRDLTSKNVLIR 238
            :|..:.||..||||.::||.|   :.....:..|:.|||||:|:|:   ..|.||||.|.||||
  Fly   199 KLCLVMEYARGGSLNRILAGK---IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLI- 259

  Fly   239 NLANDQYEAVVG-----------DFGLAAKIPVKSRKSRLETVGSPYWVSPECLKGQWYDQTSDV 292
                  |||:.|           |||||.::   ....|:...|:..|:.||.:....|.:.|||
  Fly   260 ------YEAIEGNHLQQKTLKITDFGLAREM---YNTQRMSAAGTYAWMPPEVISVSTYSKFSDV 315

  Fly   293 FSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFH 357
            :|:|::..|:|..........|.:.::|:.........|...|..:..|...|...|...||.|.
  Fly   316 WSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFK 380

  Fly   358 DATKKLTLLLEKYEHESSAGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLT 422
            :..|:                     ||.|.||       ..||||:.|.
  Fly   381 EILKQ---------------------LESIACS-------KFTLTPQESF--------------- 402

  Fly   423 PRHLQEVDEDGFRFPSKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLS 487
             .::||.        .:|..:..|               |.|:.:.:| .|.:|.|:    |:..
  Fly   403 -HYMQEC--------WRKEIAGVL---------------HDLREKEKR-FQTIEEEL----RNKE 438

  Fly   488 ENIIHFPMHTSPSDKARCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVLTLRK 552
            |.::.  :.....:||...:::.|......                            .||..|:
  Fly   439 EQLLR--VQNEQREKANLLKIREQNLRERE----------------------------RVLIERE 473

  Fly   553 VGDPQYKPTSEKDHNGSKPNPFEALAQLRGVKKILDA-NPKTYAAGVGDLFSSCFEMLAPFFKEL 616
            :...|..|:..|...|.|..|.: ::...|.:..:.| ..|....|            :|.|..|
  Fly   474 LVMLQPVPSKRKHKKGKKNKPLQ-ISLPTGFRHTITAVRDKAEQPG------------SPSFSGL 525

  Fly   617 AAMQSKAGAQG--GGTST----EETSTGNKASAATPSEPKSLPVSPHMTRKYSAIELRLPQRISN 675
            ..:....|.:|  .|.||    |.:...::.|...|..|..  .|.|.:...||..|...|:..|
  Fly   526 RIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQ--TSTHSSFSKSAPNLDKKQQQQN 588

  Fly   676 AAPPAVTSAPP------------------------PSIALPTDEDDCDDC-----------NSEG 705
            ....|..:.||                        |.|....:.::..:|           .:..
  Fly   589 QQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTT 653

  Fly   706 EDPDGGGNCADAESSSDDSAVRPSTVPTARKYRANSLYAHP-----LFRGSNGTSMKSTSTG--- 762
            .:.:...|...|.:::..:.:  ||:.:.......:|.:.|     |..|.|.::..:||..
  Fly   654 NNNNNNNNSISANNNNQLNNI--STINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAK 716

  Fly   763 ----------------EFESPTLLKA---SASTITLTASVGATNSCEDLTESARKSKEQASSGA- 807
                            .::.|.|...   |:.|.|:.:..|    |....:|...|   |:|||
  Fly   717 IYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTG----CFHFLKSGNSS---AASGAV 774

  Fly   808 -----------TAAV----QALPT-----PMSGCSTRLVETPVSVSSCTDLELDELKNTCDLNEL 852
                       :.||    .:|.:     |.:|.::..:...:::.|       |..||.|....
  Fly   775 HLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPS-------EDNNTYDHAFY 832

  Fly   853 KNSCEQLPLKTNLTRRDSIESGFFSCFN----------EESDAAITNNSFGRQLNGIGSLGFGCG 907
            ::..:::.:.:: .|.:|..||..:.:|          ::::.|.....|.|..:
  Fly   833 RDVIKKMSMASS-ERVNSKSSGDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFS---------- 886

  Fly   908 GGGNSSNCCYEKLKTQLMLDACVSADSEINDKLASLCRCCYYATSTSNAAVTAAAAAAQQQQQSH 972
            |.....:|.:.:.:.:        .::|..|.:|:     ...|:.::|.......|:|.:|
  Fly   887 GSQFPRHCFFTRQEEE--------GEAEDEDAVAA-----EVDTADADADDECQVPASQMRQ--- 935

  Fly   973 LLNDTSSTSSSVLLIDNDPAVIGGNTSSSTALDSMDDLDADIVASRRTHQRR--YTCHHAL---- 1031
              |.|:|..|||             |..|.:.:     :.|.||:.||..|.  ||...::
  Fly   936 --NSTTSRKSSV-------------TFQSVSFE-----EPDFVATPRTTARSDLYTSSASISFAT 980

  Fly  1032 -LSGNGSESQMAATASLINRLALDSEIHTLLQRSPFATNQLLYCKNRTSSIYTDSSDDISSLAGS 1095
             .|.:.|.|..:.|||....:|....::....:.    |.:|..:....   .....|:..|...
  Fly   981 YRSASPSLSSSSTTASASPSIASTEAVNGYHMQE----NSILNTRRMQD---VQPHPDVIKLRAQ 1038

  Fly  1096 DSLLWDDRSFTALPS--TRSAQIAKIVEYFERKRQD-SSPPSVHHRNGNGTVAAAVAASALGSNY 1157
            :............|.  |:|..:...||....:..| :.|...||..|:..:.|..       |.
  Fly  1039 EQRQQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALF-------NL 1096

  Fly  1158 LSYESRRYSDFKRH-----------------LNADGLCFDLDKKPAQQRMMVCE 1194
            .:...::||....|                 |...|....|.:|..:.:...||
  Fly  1097 FTRSRKKYSKLAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQTQSCE 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	85/274 (31%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	83/278 (30%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	8/56 (14%)
		TyrKc	129..386	CDD:197581	86/299 (29%)
		STKc_MLK	134..389	CDD:270963	85/296 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840