DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and limk2

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001002651.1	Gene:	limk2 / 436924	ZFINID:	ZDB-GENE-040718-398	Length:	651	Species:	Danio rerio

Alignment Length:	353	Identity:	125/353 - (35%)
Similarity:	180/353 - (50%)	Gaps:	59/353 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DATAEAPVKHQPLHNGGWIGNGLPPAPV----------TRTIS-SDRLVTGSSC--RALRTAVSA 104
            |......:|.:.|..    .|.:..:||          ||.|. |:.|.:.|||  |..|..
Zfish   278 DTVDNGTLKRRSLRR----SNSICKSPVSSSPKDHLVLTRDIGRSESLRSPSSCSHRIFRPC--- 335

  Fly   105 LYSVDDFVK-EKIGSGFFSEVYKVTHRTTGQVMVLKMNQLRAN---RPNMLREVQLLNKLSHANI 165
                 |.:. |.:|.|||.:..||||:.||:|||:| ..:|.:   :...|:||:::..|.|.::
Zfish   336 -----DLIHGEILGKGFFGQAIKVTHKATGEVMVMK-ELIRCDEETQKTFLKEVKVMRSLDHTHV 394

  Fly   166 LSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDL 230
            |.|:||..::.:|:.:||:|.||:|:..:.:.: .....|::..|..||.||:|:|...|.||||
Zfish   395 LKFIGVLYKDKRLNLITEFIEGGTLKDFIRDTD-SFPWEQRVSFAKSIASGMAYLHSMSIIHRDL 458

  Fly   231 TSKNVLIRNLANDQYEAVVGDFGLAAKI---------PVK-----------SRKSRLETVGSPYW 275
            .|.|.|:: |.|   ..||.||||:..|         |.|           .||.|...||:|||
Zfish   459 NSHNCLVK-LDN---TVVVADFGLSRLIMEDKVKQPPPDKPTNKKRLFRRIDRKKRYTVVGNPYW 519

  Fly   276 VSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVE-LCPMDTPPVFL 339
            ::||.|.|:.||:..|:|||||:.||||.::.|||:.:|||..|||:...|:| ..|...||.|.
Zfish   520 MAPEMLNGKRYDEKVDIFSFGIVLCEIIGQVYADPECLPRTLDFGLNVRTFIEKFLPEHCPPAFF 584

  Fly   340 RLAFYCCLYDAKSRPTF---HDATKKLT 364
            .||..||.....:||.|   .|..:.||
Zfish   585 ALAVACCDLTPDNRPAFQKLEDCFEALT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	106/277 (38%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	107/276 (39%)
limk2	NP_001002651.1	LIM1_LIMK2	12..64	CDD:188847
		LIM2_LIMK2	66..124	CDD:188849
		PDZ	152..234	CDD:278991
		STYKc	340..608	CDD:214568	106/273 (39%)
		STKc_LIMK2	343..615	CDD:271124	107/276 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920