DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and ksr

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	164/506 - (32%)	Gaps:	170/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QHSGPGPPSEICGLSVDQVDSSAASPFIWP------STAGMCTTATTVTTSTNGDATAEAPVKHQ 63
            ||.....||..|      ..|:.:||.::.      ..||..::|..:.|.:.|        |||
  Fly   464 QHGDSSSPSSSC------TSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLG--------KHQ 514

  Fly    64 P----------LHNGGWIGNGL----------PPAPVTRTISSDRLV------------------ 90
            |          ..:||..|..|          |.||.|.....|.||
  Fly   515 PSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNA 579

  Fly    91 ---------------TGSSC----RALRTA--------------------------VSALYSVDD 110
                           |.|:|    |.|.||                          :|...|.|.
  Fly   580 STAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDS 644

  Fly   111 -----------------------------------FVKEKIGSGFFSEVYKVTHRTTGQVMVLKM 140
                                               .:.|:||.|.|..|::....  |.|.|..:
  Fly   645 DRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWH--GDVAVKLL 707

  Fly   141 NQLRANRPNMLR----EVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVL 201
            |:......:||.    ||.......|.|::.|||.|:....|..:|....|.:|...:..:....
  Fly   708 NEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKF 772

  Fly   202 SATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDFGLAAKIPVKSRKSR 266
            :..:.:.:|..||:||.|:|...|.|:||.:||:.|.|     .:.::.||||.:...:......
  Fly   773 AMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIEN-----GKVIITDFGLFSSTKLLYCDMG 832

  Fly   267 LETVGSPY-W-----------VSPECLKGQWYDQT--SDVFSFGIIQCEIIARIEADPDMMPRTA 317
            |   |.|: |           :.||..:|:..:.|  |||:|||.:..|:|.......|....:.
  Fly   833 L---GVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESI 894

  Fly   318 SFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLE 368
            .:.:.......|..:.:......|...|..|:.:.||.|    .:|..|||
  Fly   895 IWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQF----ARLLSLLE 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	67/267 (25%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	70/271 (26%)
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277
		C1_1	368..419	CDD:278556
		PK_KSR	678..946	CDD:270965	71/278 (26%)
		Pkinase_Tyr	679..940	CDD:285015	68/274 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930