DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and LIMK2

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001026971.1	Gene:	LIMK2 / 3985	HGNCID:	6614	Length:	686	Species:	Homo sapiens

Alignment Length:	342	Identity:	126/342 - (36%)
Similarity:	179/342 - (52%)	Gaps:	35/342 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AGMCTTATTVTTSTNGDATAEAPVKHQPLHNGGWIGNGL-PPAPVTRTISSDRLVTGSSCRALRT 100
            ||.....:|:.|..|    .|..::.:.|.....|.... |.:|....:.|..:....|.|...:
Human   239 AGHPHALSTLDTKEN----LEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS 299

  Fly   101 AVSALYSVDDFVK-EKIGSGFFSEVYKVTHRTTGQVMVLKMNQLRAN---RPNMLREVQLLNKLS 161
            ....::...|.:. |.:|.|||.:..||||:.||:|||:| ..:|.:   :...|.||:::..|.
Human   300 YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK-ELIRCDEETQKTFLTEVKVMRSLD 363

  Fly   162 HANILSFMGVCVQEGQLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIF 226
            |.|:|.|:||..::.:|:.|||||.||:|:..|.:.: .....||:|.|.|||.||:|:|...|.
Human   364 HPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCII 427

  Fly   227 HRDLTSKNVLIRNLANDQYEAVVGDFGLAAKI-------PVK------------SRKSRLETVGS 272
            ||||.|.|.||:.    ....||.||||:..|       |::            .||.|...||:
Human   428 HRDLNSHNCLIKL----DKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 488

  Fly   273 PYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAFVE-LCPMDTPP 336
            |||::||.|.|:.||:|.|:|||||:.||||.::.||||.:|||..|||:...|.| ..|.|.||
Human   489 PYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPP 553

  Fly   337 VFLRLAFYCCLYDAKSR 353
            .|..||..||..:.:||
Human   554 AFFPLAAICCRLEPESR 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	112/265 (42%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	111/261 (43%)
LIMK2	NP_001026971.1	LIM	<15..44	CDD:295319
		LIM2_LIMK2	46..104	CDD:188849
		PDZ	131..215	CDD:278991
		PKc_like	316..570	CDD:328722	109/259 (42%)
		PP1_inhibitor	564..686	CDD:283108	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920