DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cdi and Raf

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	429	Identity:	118/429 - (27%)
Similarity:	177/429 - (41%)	Gaps:	71/429 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLNQHSGPGPPSEICG-------LSVDQVDSSAASPFIWPSTAGMC-TTATTVTTSTNGDATAEA 58
            |....|...|||...|       ..:.|.|.|.::|       .:| ....:||:........:|
  Fly   313 SSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSNSAP-------NVCINNIRSVTSEVQRSLIMQA 370

  Fly    59 --PVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRA-----LRTAVSA-----LYSVDDF 111
              |:.|....:    .|....:| |.|:..:|....|:..:     ||.|.|:     :.:.:..
  Fly   371 RPPLPHPCTDH----SNSTQASP-TSTLKHNRPRARSADESNKNLLLRDAKSSEENWNILAEEIL 430

  Fly   112 VKEKIGSGFFSEVYKVTHRTTGQVMVLKMN-------QLRANRPNMLREVQLLNKLSHANILSFM 169
            :..:||||.|..||:.  ...|.|.|..:|       ||:|.:    .||.:|.|..|.|||.||
  Fly   431 IGPRIGSGSFGTVYRA--HWHGPVAVKTLNVKTPSPAQLQAFK----NEVAMLKKTRHCNILLFM 489

  Fly   170 GVCVQEGQLHALTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKN 234
            | ||.:..|..:|::..|.||.:.:...|........|.:...:|:||.|:|...|.||||.|.|
  Fly   490 G-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNN 553

  Fly   235 VLIRNLANDQYEAVVGDFGLA-AKIPVKSRKSRLETVGSPYWVSPECLKGQW---YDQTSDVFSF 295
            :.:    ::.....:|||||| ||......|...:..||..|::||.::.|.   |...|||::|
  Fly   554 IFL----HEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAF 614

  Fly   296 GIIQCEIIARIEADPDMMPRTASFGLDYLAFVE----LCP------MDTPPVFLRLAFYCCLYDA 350
            ||:..|::|      :.:|.......|.:.|:.    |.|      .|.|....|||..|..|..
  Fly   615 GIVMYELLA------ECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTP 673

  Fly   351 KSRPTFHDATKKLTLLLEKYEHESSAGASP-LSSLELIN 388
            |.||.|......|..:|........:.:.| |:..:|.|
  Fly   674 KDRPLFRPLLNMLENMLRTLPKIHRSASEPNLTQSQLQN 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	86/270 (32%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	88/274 (32%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	86/268 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930