DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and Tesk1

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_113766.1	Gene:	Tesk1 / 29460	RGDID:	62059	Length:	628	Species:	Rattus norvegicus

Alignment Length:	726	Identity:	258/726 - (35%)
Similarity:	339/726 - (46%)	Gaps:	158/726 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GDATAEAPVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDF-VKEK 115
            |....|.||: .|...||..|.|.|                ||.||||:|||:|..|||| ..||
  Rat    10 GPGPGETPVE-GPGGAGGGPGRGRP----------------SSYRALRSAVSSLARVDDFDCAEK 57

  Fly   116 IGSGFFSEVYKVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHA 180
            ||:|||||||||.||.:|||||||||:|.:||.|.||||||:|:|.|.|||.||||||.:|||||
  Rat    58 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHA 122

  Fly   181 LTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQY 245
            ||||:|||:|||||::.| .||...::.|||.||:|:.|:|..|:|||||||||.|:|. .:..:
  Rat   123 LTEYMNGGTLEQLLSSPE-PLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRR-EDGGF 185

  Fly   246 EAVVGDFGLAAKIPV---KSRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIE 307
            .|||||||||.||||   .:||..|..||||||::||.|:|:.||:.:|||:|||:.||:|||:.
  Rat   186 TAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVP 250

  Fly   308 ADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEH 372
            ||||.:|||..||||..||..|...|.|..||.||.:||..:..:|..|.:.|:.|..:||:...
  Rat   251 ADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLPE 315

  Fly   373 ESSAGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPR---HLQEVDEDGF 434
            .:.....||:...|         :.|....||.          .|:.|| ||   .|.....|.|
  Rat   316 PTPLAKMPLAKAPL---------TYNQGSVPRG----------GPSATL-PRSDPRLSRSRSDLF 360

  Fly   435 RFPSKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSP 499
            ..||.:|       .|:.....:..:...|:..:|....||               :..|
  Rat   361 LPPSPES-------PPSWGDNLTRVNPFSLREDLRGGKIKL---------------LDTP----- 398

  Fly   500 SDKARCHQMQRQRSSTHSP-TPPRQLSSVQLP-----------------ATSIPDPPPLPKPVPA 546
                 |      :.:|..| .||..|:|.|||                 ..|:|..|.||:.:..
  Rat   399 -----C------KPATPLPLVPPSPLTSTQLPLVASPESLVQPETPVRRCRSLPSSPELPRRMET 452

  Fly   547 VLTLRKVGDPQYKPTSEK--DHNGSKPNPFEALAQLRGVKKILDANPKTYAAGVGDLFSSCFEML 609
            .|.  ..|.....|::|:  |..||.|.|     :..|     .|.....|....:..|:|....
  Rat   453 ALP--GPGPSPVGPSTEERMDCEGSSPEP-----EPPG-----PAPQLPLAVATDNFISTCSSAS 505

  Fly   610 APFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATPSEPKSLPVSPHMTRKYSAIELRLPQRIS 674
            .|:           .|:.|      .|..|...|...:.|:.....|....::|     ||:.
  Rat   506 QPW-----------SARPG------PSLNNNPPAVVVNSPQGWAREPWNRAQHS-----LPRA-- 546

  Fly   675 NAAPPAVTSAPPPSIALPTDEDDCDDCNSEGEDPDGGGNCADAESSSDDSAVRPSTVPTARKYR- 738
             ||......:||||  .|.::::...|          ..|..:..|....::.|...|...:||
  Rat   547 -AALERTEPSPPPS--APREQEEGLPC----------PGCCLSPFSFGFLSMCPRPTPAVARYRN 598

  Fly   739 ----ANSLYAH 745
                |.||..|
  Rat   599 LNCEAGSLLCH 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	150/252 (60%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	151/256 (59%)
Tesk1	NP_113766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		10/41 (24%)
		TyrKc	56..306	CDD:197581	150/251 (60%)
		PKc_TESK	58..313	CDD:271057	151/256 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..376		15/63 (24%)
		Required for interaction with YWHAB. /evidence=ECO:0000269\|PubMed:11555644	421..526		25/133 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..490		16/77 (21%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000269\|PubMed:17974561	529..628		22/101 (22%)
		Required for interaction with PARVA. /evidence=ECO:0000269\|PubMed:15817463	529..626		22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..568		10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	293	1.000	Domainoid score	I1450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm46162
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920