DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cdi and Tesk1

DIOPT Version :9

Sequence 1:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster
Sequence 2:	NP_035701.3	Gene:	Tesk1 / 21754	MGIID:	1201675	Length:	627	Species:	Mus musculus

Alignment Length:	739	Identity:	259/739 - (35%)
Similarity:	337/739 - (45%)	Gaps:	185/739 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GDATAEAPVKHQPLHNGGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDF-VKEK 115
            |....||| ...|...||..|.|.|                ||.||||:|||:|..|||| ..||
Mouse    10 GPGPGEAP-GEGPGGAGGGPGRGRP----------------SSYRALRSAVSSLARVDDFDCAEK 57

  Fly   116 IGSGFFSEVYKVTHRTTGQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHA 180
            ||:|||||||||.||.:|||||||||:|.:||.|.||||||:|:|.|.|||.||||||.:|||||
Mouse    58 IGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHA 122

  Fly   181 LTEYINGGSLEQLLANKEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQ- 244
            ||||:|||:|||||::.| .||...::.|||.||:|:.|:|..|:|||||||||.|:|.  .|:
Mouse   123 LTEYMNGGTLEQLLSSPE-PLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRR--EDRG 184

  Fly   245 YEAVVGDFGLAAKIPV---KSRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARI 306
            :.|||||||||.||||   .:||..|..||||||::||.|:|:.||:.:|||:|||:.||:|||:
Mouse   185 FTAVVGDFGLAEKIPVYREGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARV 249

  Fly   307 EADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYE 371
            .||||.:|||..||||..||..|...|.|..||.||.:||..:..:|..|.:.|:.|..:||:..
Mouse   250 PADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQP 314

  Fly   372 HESSAGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPR---HLQEVDEDG 433
            ..:.....||:...|         :.|....||.          .|:.|| ||   .|.....|.
Mouse   315 EATPLAKPPLTKAPL---------TYNQGSVPRG----------GPSATL-PRPDPRLSRSRSDL 359

  Fly   434 FRFPSKKSASAALPGTPNGSAGSSGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTS 498
            |..||.:|       .|:.....:..:...|:..:|....||               :..|
Mouse   360 FLPPSPES-------PPSWGDNLTRVNPFSLREDLRGGKIKL---------------LDTP---- 398

  Fly   499 PSDKARCHQMQRQRSSTHSP-TPPRQLSSVQLP-----------------ATSIPDPPPLPKPVP 545
                  |      :.:|..| .||..|:|.|||                 ..|:|..|.||:.:.
Mouse   399 ------C------KPATPLPLVPPSPLTSTQLPLVTTPDILVQPETPVRRCRSLPSSPELPRRME 451

  Fly   546 AVLTLRKVGDPQYKPTSEK-DHNGSKPNPFEALAQLRGVKKILDANPKTYAAGVGDLFSSCFEML 609
            ..|.  ..|.....||.|: |..||.|.|     :..|:     |.....|....:..|:|
Mouse   452 TALP--GPGPSPMGPTEERMDCEGSSPEP-----EPPGL-----APQLPLAVATDNFISTC---- 500

  Fly   610 APFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATPSEPKSLPVSPHMTRKYSAIELRLPQ--- 671
                                           :||:.|..|:|   .|.:.....|:.:..||
Mouse   501 -------------------------------SSASQPWSPRS---GPPLNNNPPAVVVNSPQGWA 531

  Fly   672 -----RISNAAPPAVT-----SAPPPSIALPTDEDDCDDCNSEGEDPDGGGNCADAESSSDDSAV 726
                 |..::.|.|..     .:||||  .|.:.::...|          ..|.....|....::
Mouse   532 REPWNRAQHSLPRAAALERTEPSPPPS--APREPEEGLPC----------PGCCLGPFSFGFLSM 584

  Fly   727 RPSTVPTARKYR-----ANSLYAH 745
            .|...|...:||     |.||..|
Mouse   585 CPRPTPAVARYRNLNCEAGSLLCH 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	151/253 (60%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	152/257 (59%)
Tesk1	NP_035701.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		11/42 (26%)
		TyrKc	56..306	CDD:197581	151/252 (60%)
		PKc_TESK	58..312	CDD:271057	151/256 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..373		18/83 (22%)
		Required for interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q63572	421..525		27/153 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..485		16/60 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..519		7/56 (13%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q63572	528..627		20/93 (22%)
		Required for interaction with PARVA. /evidence=ECO:0000250\|UniProtKB:Q63572	528..625		20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..565		8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1514
eggNOG	1	0.900	-	-		E2759_2QTCP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119463at33208
OrthoFinder	1	1.000	-	-		FOG0003575
OrthoInspector	1	1.000	-	-		otm44072
orthoMCL	1	0.900	-	-		OOG6_104336
Panther	1	1.100	-	-	LDO	PTHR46485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780