Protein Alignment cdi and TESK2

DIOPT Version :10

• Sequence 1: NP_524401.2
• Gene: cdi / 42289
• FlyBaseID: FBgn0004876
• Length: 1213
• Species: Drosophila melanogaster
• Sequence 2: NP_009101.2
• Gene: TESK2 / 10420
• HGNCID: 11732
• Length: 571
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 244/688 - (35%)
• Similarity: 311/688 - (45%)
• Gaps: 188/688 - (27%)

  Fly    68 GGWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVKEKIGSGFFSEVYKVTHRTT 132
            ||..|.|        .:|....|..||.|||.:|.|.|..:|||..|||||||||||:||.||.:
Human    24 GGGGGEG--------NVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRAS 80

  Fly   133 GQVMVLKMNQLRANRPNMLREVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGSLEQLLANK 197
            ||||.||||.|.:||.|||:||||:|:|||.|||.||||||.:|||||||||||.|:||||| :.
Human    81 GQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLL-DS 144

  Fly   198 EVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLIRNLANDQYEAVVGDFGLAAKIP-VK 261
            .:.|..|.:::||..||.|:||:|..|||||||||||.||:...|. |.|||.|||||.||| |.
Human   145 NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENG-YSAVVADFGLAEKIPDVS 208

  Fly   262 SRKSRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASFGLDYLAF 326
            ....:|..||||:|::||.|:.:.|::.:||||:|||.|||||||:||||.:|||.:|||||.||
Human   209 MGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF 273

  Fly   327 VELCPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESSAGASPLSSLELINCSP 391
            ..:.. |.||.||:|.|.||..|.|.||:|.:..|.|..:|.:.:.|
Human   274 QHMVG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEE------------------ 319

  Fly   392 GGSDSENVTLTPRASVPTVATICTAPAGTLTPRHLQEVDEDGFRFPSKKSASAALPGTPNGSAGS 456
                                                |.:.|....|:.:......||...    .
Human   320 ------------------------------------EQERDRKLQPTARGLLEKAPGVKR----L 344

  Fly   457 SGFDDHILKSRVRRATQKLEAEILLHRRSLSENIIHFPMHTSPSDKARCHQMQRQRSSTHSPTPP 521
            |..||.|                               .|.||..: |...:.|.:|...|..||
Human   345 SSLDDKI-------------------------------PHKSPCPR-RTIWLSRSQSDIFSRKPP 377

  Fly   522 RQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQYKPTSEKDHNGS----KPNPFEALAQLRG 582
            |.:|                           |.||.|:|     .:|:    |.|||.|...|.|
Human   378 RTVS---------------------------VLDPYYRP-----RDGAARTPKVNPFSARQDLMG 410

  Fly   583 VK-KILDANPKTYAAGVGDLFSSCFEMLAPFFKELAAMQSKAGAQGGGTSTEETSTGNKASAATP 646
            .| |..|...|:       :.|..|::.||               |.||..       .|....|
Human   411 GKIKFFDLPSKS-------VISLVFDLDAP---------------GPGTMP-------LADWQEP 446

  Fly   647 SEP-----KSLPVSPHMTRKYSAIELRLPQRISNAAPPAVTSAP------PP--SIALPTDE-DD 697
            ..|     :|||.||....:.:...:...:.:|:..||.::|..      ||  :.|||..: .:
Human   447 LAPPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQAHE 511

  Fly   698 CDDC------NSEGEDPDGGGNCADAESSSDDSAVRPS 729
            ..||      |..|..|.|...|....|...:...||:
Human   512 AMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPA 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cdi	NP_524401.2	Protein Kinases, catalytic domain	116..370	CDD:473864	153/254 (60%)
TESK2	NP_009101.2	PKc_TESK	64..316	CDD:271057	153/254 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..571		8/29 (28%)