Protein Alignment CG6026 and HCN2

DIOPT Version :10

• Sequence 1: NP_650778.2
• Gene: CG6026 / 42287
• FlyBaseID: FBgn0038676
• Length: 1555
• Species: Drosophila melanogaster
• Sequence 2: NP_001185.3
• Gene: HCN2 / 610
• HGNCID: 4846
• Length: 889
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 59/321 - (18%)
• Similarity: 90/321 - (28%)
• Gaps: 147/321 - (45%)

  Fly   865 PAQQPGEQPSLEMEPPPRYPTTVPVAHAPPTPGKRPLGTSPPSNFYNEYNRKPQNGPRPSNLPNI 929
            |.:.||..|:....|||           ||.|                    ||..|.|
Human    10 PGESPGATPAPGPPPPP-----------PPAP--------------------PQQQPPP------ 37

  Fly   930 LPQFRPNAKISSGHPPALKQEPGNIRLPQQGGPGPKRPYNP----AMQPQFAHRRQPLHQQHQQM 990
                          ||.....|         ||||..|.:|    |:.|:.|....|    ..::
Human    38 --------------PPPPAPPP---------GPGPAPPQHPPRAEALPPEAADEGGP----RGRL 75

  Fly   991 MQKRYPMNRISEYPVGPG--------PGGDVNRRVYRLPPYGGQNVPYMPDHMYPRRPQGAGPLR 1047
            ..:.....|    |..||        |.|:..|...:..|.|.:.....|...:..|...:||
Human    76 RSRDSSCGR----PGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARGPKVSFSCRGAASGP-- 134

  Fly  1048 SVDGYPAERHAPSSEPYKTIDAEAAADFEEEDLVINDPPQPVTPGKDRKGTEET--------KLE 1104
                      ||...|.:...:|.|.                 |..:.:|::.:        .|:
Human   135 ----------APGPGPAEEAGSEEAG-----------------PAGEPRGSQASFMQRQFGALLQ 172

  Fly  1105 PVV---TLQMLQSQKKAVSLPGDDTGAGEIQVTADNDPQEAEASKLSQQKLDPSGMYVVFP 1162
            |.|   :|:|..|||                           |.:..|:::..:|.:::.|
Human   173 PGVNKFSLRMFGSQK---------------------------AVEREQERVKSAGAWIIHP 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6026	NP_650778.2	PHA03378	<792..975	CDD:223065	24/113 (21%)
HCN2	NP_001185.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..159		47/245 (19%)
		PBP1	<57..185	CDD:444064	29/164 (18%)
		PLN03192	150..>688	CDD:215625	14/101 (14%)
		Involved in subunit assembly. /evidence=ECO:0000250	158..209		12/76 (16%)
		CAP_ED	544..652	CDD:237999
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..889