DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6026 and HCN1

DIOPT Version :10

Sequence 1:NP_650778.2 Gene:CG6026 / 42287 FlyBaseID:FBgn0038676 Length:1555 Species:Drosophila melanogaster
Sequence 2:NP_066550.2 Gene:HCN1 / 348980 HGNCID:4845 Length:890 Species:Homo sapiens


Alignment Length:421 Identity:91/421 - (21%)
Similarity:158/421 - (37%) Gaps:94/421 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 ALLPLEARSADVSGEEDVISTSYVLPNQIFNEGKPYYARQDPVSGQLDFSAKKPAGIQPEANEVL 98
            |.:||.| :||.:....::|.   |..::|..| .|..|:..|..::.|.....||:      :.
Human   471 ATMPLFA-NADPNFVTAMLSK---LRFEVFQPG-DYIIREGAVGKKMYFIQHGVAGV------IT 524

  Fly    99 DPNEKIVLSGGS--------------------------SPNIHDFLNLPVKYSSSKFVYPLVS-- 135
            ..::::.|:.||                          |.::.:|..:..:|...:..:..|:  
Human   525 KSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 589

  Fly   136 --------SSYANLKYQGSNKNYITNKKPTSV--------------VAPVT-PPPPNYHSSNFFT 177
                    :|....|:|......:.|.:...:              :||:. |.....:|::..|
Human   590 RLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTT 654

  Fly   178 VPTTKLTAVTP---TAGAYYPS---SPSTSTSTTTSTSTTTTTTTTTRGTLPPSRKPVTTTTTTA 236
            .||:::...:|   ||.:...|   |||.||.|...::..:..:.||....||.:.|:...|...
Human   655 TPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHY 719

  Fly   237 PTSPAAKYTTTSRRP-------IPLQTVSTTPQP-PRT--STTRKKFV--------PTKKYSPTV 283
            .:..|::.:...::|       .|.||....|.| |:|  |:|.|..|        .|.......
Human   720 ASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVR 784

  Fly   284 PSTSGRPTVGHEDQRPVKSSPRPTPSSSDVALTTH-HATP----QAAIFPTEPVTTTKMYTTSST 343
            |.::.:|::.||....: |.|.||...|..::... .|.|    ||....|.|...|.....||.
Human   785 PLSASQPSLPHEVSTLI-SRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSG 848

  Fly   344 SAPVVFTEGPTPPPAFSPIP--GTGIPNLDP 372
            :.|......|.|||..:.:|  .:.:.|.||
Human   849 AIPPNRGVPPAPPPPAAALPRESSSVLNTDP 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6026NP_650778.2 PHA03378 <792..975 CDD:223065
HCN1NP_066550.2 Disordered. /evidence=ECO:0000305|PubMed:28086084 1..93
Ion_trans_N 98..140 CDD:400630
PLN03192 133..>620 CDD:215625 27/159 (17%)
Selectivity filter. /evidence=ECO:0000305|PubMed:28086084 358..362
CAP_ED 475..583 CDD:237999 20/118 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..692 14/47 (30%)
PRK10263 <662..>842 CDD:236669 46/180 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..796 15/70 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 845..890 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.

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