Protein Alignment CG6026 and CNGB1

DIOPT Version :10

• Sequence 1: NP_650778.2
• Gene: CG6026 / 42287
• FlyBaseID: FBgn0038676
• Length: 1555
• Species: Drosophila melanogaster
• Sequence 2: NP_001288.3
• Gene: CNGB1 / 1258
• HGNCID: 2151
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 152/706 - (21%)
• Similarity: 228/706 - (32%)
• Gaps: 226/706 - (32%)

  Fly   678 LPPPPNFQQMPSIQQNSNFHQNGNVATSGAPGTISYQEPPPEAPTPYQQLPLIGSNKRPSKKPVT 742
            ||.||...:...:|:....                  ||.||          :.:...|...| .
Human     9 LPQPPGTPRKTKMQEEEEV------------------EPEPE----------MEAEVEPEPNP-E 44

  Fly   743 KPEQPSHSYPPQQSSTPQK---PQPTPPVLMQGEDTKELLVSTNIRFPAQGEE--SLEPPSSAVM 802
            :.|..|.|.||::|...::   ..|:|      ::|||..:::.|...|||.|  .:..||..|
Human    45 EAETESESMPPEESFKEEEVAVADPSP------QETKEAALTSTISLRAQGAEISEMNSPSRRV- 102

  Fly   803 QGPPAGPNINGHAQPLSLQQIQNSNPVVFPKPMDEVVPGSASVQIQQH----EVLNLSQQKQPLK 863
                             |..:......|.|:|:..:....|  ||..|    :.....:..:.|:
Human   103 -----------------LTWLMKGVEKVIPQPVHSITEDPA--QILGHGSTGDTGCTDEPNEALE 148

  Fly   864 FPAQQPG-------EQPSLE--MEPPPR-------YPTTVPVAHAPPTPGKRPLGTSPPSNFYNE 912
            ....:||       || :||  :..||:       .|.....|.:.|.|..||          .|
Human   149 AQDTRPGLRLLLWLEQ-NLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRP----------QE 202

  Fly   913 YNRKPQNGPRPSNLPNILPQFRPNAKISSGHPPALKQEPGNIRLPQQGGPGPK-RPYNPAMQPQF 976
            ...|.|....|| ||..:| .:|            |:||       :..|.|: :|.:.|.....
Human   203 MGPKLQARETPS-LPTPIP-LQP------------KEEP-------KEAPAPEPQPGSQAQTSSL 246

  Fly   977 AHRRQP-------LHQQHQQMMQKRYPM--NRISEY-PVGPG----------PGGDVNRRVYRLP 1021
            ...|.|       ||:....:.|   |:  .:|.|. |..||          |||.|.      |
Human   247 PPTRDPARLVAWVLHRLEMALPQ---PVLHGKIGEQEPDSPGICDVQTISILPGGQVE------P 302

  Fly  1022 PYGGQNV--PYMPDHM-YPRRPQGAGPLRSVDGYPAERHAPSSEPYKTIDAEAAADFEEEDLVIN 1083
            ....:.|  |:...|. ....|||.   ..|..|..|..|....|.:....|...:.|||:
Human   303 DLVLEEVEPPWEDAHQDVSTSPQGT---EVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE---- 360

  Fly  1084 DPPQPVTPGKDRKGTEETKLEPVVTLQMLQSQKKAVSLPGDDTGAGEI-------QVTADNDPQE 1141
                        :..||.:.|..||..:|.|  ..||    ..|.|:.       |.|:|....|
Human   361 ------------EEEEEEEEEEEVTEVLLDS--CVVS----QVGVGQSEEDGTRPQSTSDQKLWE 407

  Fly  1142 ---AEASKLSQQKLDPSGMYVVFPMKSAEKGQSE----GDAPSAPAEYQNTPFSVIRDQPQEPIL 1199
               .||.|.:::|.......|.  .:.|||...:    .:.|.|.||..::.....:..|:..:
Human   408 EVGEEAKKEAEEKAKEEAEEVA--EEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQV- 469

  Fly  1200 KNKKPQSLQQQNKAQHVPKDKFPYPIEKPDPSFSELHPESQTSVSGVLVAPRIITGAMGT----- 1259
                          :....|..|...|:..|| :.|.|.|... |..|:.|   :.|.||
Human   470 --------------EDTDADSCPLMAEENPPS-TVLPPPSPAK-SDTLIVP---SSASGTHRKKL 515

  Fly  1260 --------------GTETPIAIAYTPTEPNPFRHEQGQKFSNINLATSVINEIRQD 1301
                          ..|:|:.....||.|.. ...|.:..|..:..:::||:..|:
Human   516 PSEDDEAEELKALSPAESPVVAWSDPTTPKD-TDGQDRAASTASTNSAIINDRLQE 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6026	NP_650778.2	PHA03378	<792..975	CDD:223065	43/205 (21%)
CNGB1	NP_001288.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		19/100 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..151		5/31 (16%)
		PRK10263	<167..>311	CDD:236669	42/183 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..252		25/110 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..561		62/294 (21%)
		Calmodulin-binding CaM1. /evidence=ECO:0000250|UniProtKB:Q28181	557..567		2/9 (22%)
		IQ-like	568..578		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..619
		PLN03192	648..>1034	CDD:215625
		Ion conduction pathway. /evidence=ECO:0000305|PubMed:34699778	786..885
		C-linker. /evidence=ECO:0000305|PubMed:34699778	888..964
		CAP_ED	962..1071	CDD:237999
		Cyclic nucleotide-binding domain. /evidence=ECO:0000305|PubMed:34699778, ECO:0007744|PDB:7RHI	968..1084
		Calmodulin-binding CaM2. /evidence=ECO:0000250|UniProtKB:Q28181	1148..1154
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1151..1251