Protein Alignment Prp18 and Prpf18

DIOPT Version :10

• Sequence 1: NP_650776.1
• Gene: Prp18 / 42285
• FlyBaseID: FBgn0027784
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001343380.1
• Gene: Prpf18 / 67229
• MGIID: 1914479
• Length: 351
• Species: Mus musculus
• Alignment Length: 349
• Identity: 175/349 - (50%)
• Similarity: 233/349 - (66%)
• Gaps: 17/349 - (4%)

  Fly     1 MDILKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYIKQESVEAQGQ------- 58
            |||||:||.|||:|:|.|.|:.|.||||:|.:|..|..|...::.|| |..|.:..|:
Mouse     1 MDILKSEILRKRQLVEDRNLLVENKKYFKRSELARKEEEAYYERCGY-KPVSEKPSGEIQPKEDD 64

  Fly    59 ----TTEGAYSFVADGQNILP----RTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEAN 115
                |:......:...:..||    |.|||||||||||||.:||||:.:||.|||:.||..||.|
Mouse    65 QKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPIRLFGETDYDAFQRLRKIEILTPEVN 129

  Fly   116 RGFRNDFQEAMEQVDAAYLQEMFANTPTTKEDKKSDFAELDESVSWESIQTMAANMGRNKDY-DM 179
            :|.|||.:.|::::|..||.|:.......:||.::|....:|:.:.|.::.:..::|:..|: ||
Mouse   130 KGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDM 194

  Fly   180 DVIITLLTFLLKLWNDQIANYSKHEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPEDILDSL 244
            |:|...|.|||.:|..::.....:.|.|.:.|:......||:.|::||||||:...||.||.:|:
Mouse   195 DIITKFLKFLLGVWAKELNAREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESI 259

  Fly   245 RDICKHLLNRNYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYI 309
            .||.|.:|.|.|:.|:||||:|||||||||||||||||||||||||||||:||||:|||||||||
Mouse   260 TDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYI 324

  Fly   310 QGLKRLMTKCQEYFPTDPSKCVEY 333
            ||||||||.||::|||||||||||
Mouse   325 QGLKRLMTICQKHFPTDPSKCVEY 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp18	NP_650776.1	SFM	74..117	CDD:128776	30/46 (65%)
		Prp18	184..324	CDD:460720	85/139 (61%)
Prpf18	NP_001343380.1	SFM	88..131	CDD:128776	28/42 (67%)
		Prp18	199..339	CDD:460720	85/139 (61%)