DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp18 and prp-18

DIOPT Version :9

Sequence 1:	NP_650776.1	Gene:	Prp18 / 42285	FlyBaseID:	FBgn0027784	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_501776.2	Gene:	prp-18 / 177840	WormBaseID:	WBGene00009320	Length:	352	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	131/359 - (36%)
Similarity:	197/359 - (54%)	Gaps:	41/359 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYI--KQESV------EAQGQTT 60
            |.||:|:|||.:...::.:...|:.:..||..|..:|..:|...|  |:..|      |:..:|.
Worm     7 LLAEMAKKRKAVSGMEVKEGNAKFVKGADLEMKRNQEYERKQQEIASKKRKVDDEILQESSSRTK 71

  Fly    61 EGAYSFVADGQNILPRTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEANRGFRNDFQEA 125
            .......::.....|.:|:..|||:|..||::||||:.:...||.|.|::||:.|.|:.|:.|.|
Worm    72 PAPVENESEIDEKTPMSEIQTRLRQRNHPIMLFGETDIDVRKRLHQLELAQPDLNEGWENELQTA 136

  Fly   126 M----EQVDAAYLQEMFANTPTTKEDKKSDFA--ELDESVSWESIQTMAANMGRNKDY--DMDVI 182
            |    :::|.|.::      .|.....:.|.|  :..|..:|::|:..:..:..:.|.  |.|:|
Worm   137 MKVIGKEMDKAVVE------GTADSATRHDIALPQGYEEDNWKNIEHNSTLLSVDDDLKRDCDII 195

  Fly   183 ITLLTFLLKLW----NDQIANYSK-----HEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPE 238
            :::..::|..|    ||:..:..|     ||....|         ||..::|.|...::.:....
Worm   196 LSICRYILARWAKDLNDRPLDVKKTAQGMHEAAHHK---------QTMMHLKSLMTSMERYNCNN 251

  Fly   239 DILDSLRDICKHL-LNRNYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMND 302
            ||...|..||:.| ::|||:.|::||:||||||||||:|||..|||.|.|..|.:..|:|||:||
Worm   252 DIRHHLAKICRLLVIDRNYLEANNAYMEMAIGNAPWPVGVTRSGIHQRPGSAKSYVSNIAHVLND 316

  Fly   303 ETQRKYIQGLKRLMTKCQEYFPTDPSKCVEYVSK 336
            ||||||||..||||||.||||||||||.||:|.|
Worm   317 ETQRKYIQAFKRLMTKMQEYFPTDPSKSVEFVKK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp18	NP_650776.1	SFM	74..117	CDD:128776	19/42 (45%)
Prp18	NP_650776.1	Prp18	186..322	CDD:280929	64/145 (44%)
prp-18	NP_501776.2	SFM	85..128	CDD:128776	19/42 (45%)
prp-18	NP_501776.2	Prp18	199..336	CDD:367213	64/145 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162514
Domainoid	1	1.000	128	1.000	Domainoid score	I3312
eggNOG	1	0.900	-	-		E1_KOG2808
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2726
Inparanoid	1	1.050	213	1.000	Inparanoid score	I2352
Isobase	1	0.950	-	0	Normalized mean entropy	S2129
OMA	1	1.010	-	-		QHG54709
OrthoDB	1	1.010	-	-		D1485522at2759
OrthoFinder	1	1.000	-	-		FOG0004368
OrthoInspector	1	1.000	-	-		oto18167
orthoMCL	1	0.900	-	-		OOG6_102077
Panther	1	1.100	-	-	LDO	PTHR13007
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R988
SonicParanoid	1	1.000	-	-		X3091
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750