DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp18 and Prpf18

DIOPT Version :9

Sequence 1:	NP_650776.1	Gene:	Prp18 / 42285	FlyBaseID:	FBgn0027784	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_038951256.1	Gene:	Prpf18 / 171552	RGDID:	708550	Length:	361	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	154/326 - (47%)
Similarity:	212/326 - (65%)	Gaps:	17/326 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYIKQESVEAQGQ------- 58
            |||||:||.|||:|:|.|.|:.|.||||:|.:|..|..|...::.|| |..|.:..|:
  Rat     1 MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFERCGY-KPISEKPSGEVQPKEDD 64

  Fly    59 ----TTEGAYSFVADGQNILP----RTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEAN 115
                |:......:...:..||    |.||||||||||||:.:||||:.:||.|||:.||..||.|
  Rat    65 QKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPMRLFGETDYDAFQRLRKIEILTPEVN 129

  Fly   116 RGFRNDFQEAMEQVDAAYLQEMFANTPTTKEDKKSDFAELDESVSWESIQTMAANMGRNKDY-DM 179
            :|.|||.:.|::::|..||.|:.......:||.::|....:|:.:.|.::.:..::|:..|: ||
  Rat   130 KGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVHEENTTIEELEALGESLGKGDDHKDM 194

  Fly   180 DVIITLLTFLLKLWNDQIANYSKHEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPEDILDSL 244
            |:|...|.|||.:|..::.:...:.|.|.:.|:......||:.|::||||||:...||.||.:|:
  Rat   195 DIITKFLKFLLGVWAKELNSREDYVKRSVQGKLNSATQKQTESYLRPLFRKLRKRNLPADIKESI 259

  Fly   245 RDICKHLLNRNYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYI 309
            .||.|.:|.|.|:.|:||||:|||||||||||||||||||||||||||||:||||:|||||||||
  Rat   260 TDIIKFMLQREYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYI 324

  Fly   310 Q 310
            |
  Rat   325 Q 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp18	NP_650776.1	SFM	74..117	CDD:128776	29/46 (63%)
Prp18	NP_650776.1	Prp18	186..322	CDD:280929	76/125 (61%)
Prpf18	XP_038951256.1	SFM	88..131	CDD:128776	27/42 (64%)
Prpf18	XP_038951256.1	Prp18	200..325	CDD:397123	74/124 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346083
Domainoid	1	1.000	185	1.000	Domainoid score	I3300
eggNOG	1	0.900	-	-		E1_KOG2808
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2726
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2306
OMA	1	1.010	-	-		QHG54709
OrthoDB	1	1.010	-	-		D1485522at2759
OrthoFinder	1	1.000	-	-		FOG0004368
OrthoInspector	1	1.000	-	-		oto97478
orthoMCL	1	0.900	-	-		OOG6_102077
Panther	1	1.100	-	-	LDO	PTHR13007
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770