DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp18 and prpf18

DIOPT Version :9

Sequence 1:	NP_650776.1	Gene:	Prp18 / 42285	FlyBaseID:	FBgn0027784	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_002932023.2	Gene:	prpf18 / 100170196	XenbaseID:	XB-GENE-5838397	Length:	342	Species:	Xenopus tropicalis

Alignment Length:	339	Identity:	178/339 - (52%)
Similarity:	233/339 - (68%)	Gaps:	6/339 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILKAEIARKRKLLEQRQLVDEKKKYFRRGDLNAKNTEEVLQKVGYIKQ-ESVEAQGQTTEGAY 64
            |||||||||||||.||.::|:..:||||:|.:|..|..|...::.||..| |..|.:..::....
Frog     1 MDILKAEIARKRKQLEAKELLGGEKKYFKRSELAEKEREAYFERCGYKTQMEGEEEKPSSSSNPV 65

  Fly    65 SFVADGQNILP----RTEVIRRLRERGEPILIFGETEPEAFDRLRQCEISQPEANRGFRNDFQEA 125
            ..:...:..||    |.|||||||||.|||.:||||:.|:|.|||:.||..||.|:|.|||.:.|
Frog    66 LELELAEEKLPMTLSRQEVIRRLRERAEPIRLFGETDYESFQRLRKIEILAPEVNKGLRNDLKAA 130

  Fly   126 MEQVDAAYLQEMFANTPTTKEDKKSDFAELDESVSWESIQTMAANMGR-NKDYDMDVIITLLTFL 189
            ::::|..||.|:.|...||:||.::|....:|:.:.|.::.:...:|: |.:.|||:|..:|.||
Frog   131 LDKIDQQYLNELVAGQETTEEDTQNDLKVHEENTTIEELEALGECLGQGNDNKDMDIINKVLKFL 195

  Fly   190 LKLWNDQIANYSKHEKMSTKVKMTRVIYTQTKEYVKPLFRKLKHHTLPEDILDSLRDICKHLLNR 254
            |.:|..::.....:.|.|...|:......||:.|:|||||||:...||.||.:|:.||.|.:|.|
Frog   196 LGVWAKELNAREDYVKRSVHGKLASATQKQTESYLKPLFRKLRKKNLPADIKESITDIIKFMLQR 260

  Fly   255 NYITASDAYLEMAIGNAPWPIGVTMVGIHARTGREKIFSKNVAHVMNDETQRKYIQGLKRLMTKC 319
            .|:.|:||||:|||||||||||||||||||||||||||||:||||:|||||||||||||||||.|
Frog   261 EYVKANDAYLQMAIGNAPWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTVC 325

  Fly   320 QEYFPTDPSKCVEY 333
            |:||.|||||||||
Frog   326 QKYFSTDPSKCVEY 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp18	NP_650776.1	SFM	74..117	CDD:128776	29/46 (63%)
Prp18	NP_650776.1	Prp18	186..322	CDD:280929	86/135 (64%)
prpf18	XP_002932023.2	SFM	79..122	CDD:128776	27/42 (64%)
prpf18	XP_002932023.2	Prp18	192..328	CDD:367213	86/135 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3402
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2726
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2332
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1485522at2759
OrthoFinder	1	1.000	-	-		FOG0004368
OrthoInspector	1	1.000	-	-		oto104170
Panther	1	1.100	-	-	LDO	PTHR13007
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R988
SonicParanoid	1	1.000	-	-		X3091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190