Protein Alignment GatA and HER2

DIOPT Version :10

• Sequence 1: NP_650775.2
• Gene: GatA / 42283
• FlyBaseID: FBgn0260779
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_014021.1
• Gene: HER2 / 855338
• SGDID: S000004907
• Length: 464
• Species: Saccharomyces cerevisiae
• Alignment Length: 525
• Identity: 161/525 - (30%)
• Similarity: 259/525 - (49%)
• Gaps: 99/525 - (18%)

  Fly     1 MRRHLQWSIKQLTASYSDGQLSPRRVTEDALQDALRWKTLNAFVRLTPEQAGQQAQDAEQRYKL- 64
            ::|.|:.||::|::..|                     ..|.|..:.|..           |.:
Yeast     3 LKRSLKESIERLSSFQS---------------------KYNIFTSINPSP-----------YSIT 35

  Fly    65 --RQPISDLDGVTIAIKDNFCTKDVHTTCASRMLQDFVPPYDATVCSRLKQAGAVILGKTNMDQF 127
              :.....|.|...:||||..|||..|||||.:|::|..|:||||...|||||..||||||:|:|
Yeast    36 NKKGTKETLTGCVASIKDNIVTKDFPTTCASHILENFKSPFDATVVKLLKQAGVHILGKTNLDEF 100

  Fly   128 AMGAGTVDSLYGPTKNIWSEDLNKDHWRIAGGSSGGSASAVAAGLCYAAIGSDTGGSTRNPASYC 192
            .||:|.|.|:.||..|......:|   :|.||||.|:|::||..|...|:|:|||||.|.||.|.
Yeast   101 GMGSGGVHSIRGPVINPLYPHEDK---KIMGGSSSGAAASVACDLVDFALGTDTGGSVRLPACYG 162

  Fly   193 GVVGLKPTYGLVSRHGLIPLVNSMDVPGIFARSVSDCVAVLNTVAGPDKLDSTT----------- 246
            .|:|.||:||.:||.|:|....|:|..||.::.::....|.:|:...|..|.|:
Yeast   163 SVLGFKPSYGRLSRFGVIAYSQSLDTVGILSKKINVLRKVFHTLDKYDMKDPTSLSVELRELIEG 227

  Fly   247 ---IRQPFTRLHLPEVGQIDLSTVRIGIPKEYH-------CHGLSAEVLETWSKVADLLECSGAS 301
               :|:|                :::||.||:.       .|.|...:||   |:.:|    |..
Yeast   228 NKKVRRP----------------LKVGIVKEFSHESMPIGFHRLYLSLLE---KLINL----GLE 269

  Fly   302 VRQVSLPNTAASIFVYTILNQCEVASNMARYDGIEYGHRATD-ERSTEQLYALSRAEGFNDVVKT 365
            :..||:|:....:.:|..|:..|.|||::|||||.||:|.:: :.....|:|.:|:: |...||.
Yeast   270 IYPVSIPSVKNCLPIYYTLSPAEAASNLSRYDGIRYGYRDSELDIKDGILFAPTRSK-FGTEVKN 333

  Fly   366 RILTGNFLLLKKNYDHYFEKALRVRRLIAEDFARVF-------DSSAKEERVDILLTPTTLTEAP 423
            ||:.||:.|....:.:.|.||.::|..:.::|..:|       :|....:.:|:|:.||:.....
Yeast   334 RIILGNYNLCSDAFKNNFIKAEKLRVNLIDEFDGIFRFPNVLTNSKGNPDGLDLLIVPTSSKLPG 398

  Fly   424 LYKDFASLTNRD--QCAVQDFCTQPANMAGIPAVSIPIRLSQAGLPLSLQLMSNSLNEQLLLTVA 486
            ..:||.....:.  ...:.|..|.|.::||:|::|:|::   ...|:.||::....::.   ||.
Yeast   399 SIRDFEEEEAKSPANSYINDVFTVPMSLAGLPSLSMPLK---EKTPIGLQVVGQYGDDS---TVL 457

  Fly   487 RWIEA 491
            .::|:
Yeast   458 DFVES 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GatA	NP_650775.2	GatA	1..491	CDD:439924	160/523 (31%)
HER2	NP_014021.1	gatA	1..464	CDD:272925	161/525 (31%)