DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GatA and faah

DIOPT Version :9

Sequence 1:	NP_650775.2	Gene:	GatA / 42283	FlyBaseID:	FBgn0260779	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_001103295.1	Gene:	faah / 569067	-ID:	-	Length:	590	Species:	Danio rerio

Alignment Length:	573	Identity:	137/573 - (23%)
Similarity:	218/573 - (38%)	Gaps:	168/573 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SIKQLTASYSDGQLSPRRVTEDALQDALRWKT------LNAFVRLTPEQAGQQAQDAEQRYKLRQ 66
            |:.:||....||.|.|     ||:..|...||      ||....:..|...|......|:..|
Zfish    84 SLSELTGKLQDGSLQP-----DAVLYAFMEKTLEVNRNLNCGTEMLMESVAQLKDMNTQKKGL-- 141

  Fly    67 PISDLDGVTIAIKDNFCTKDVHTTC--ASRMLQDFVPPYDATVCSRLKQAGAVILGKTNMDQFAM 129
                |.||.|:|||||..|...::|  .|::.|..|  .|:.:.:.||:.||:...|||:.|..:
Zfish   142 ----LYGVPISIKDNFGYKGHDSSCGVVSKLDQPAV--MDSVIVTVLKKQGAIPFIKTNIPQGLL 200

  Fly   130 GAGTVDSLYGPTKNIWSEDLNKDHWRIAGGSSGGSASAVAAGLCYAAIGSDTGGSTRNPASYCGV 194
            .....:.::|.|.|.:  :|.|    .:||||||..:.:..|.....:|:|.|||.|.|:::||:
Zfish   201 NYDCGNPIFGQTLNPY--NLQK----TSGGSSGGEGALIGGGGSILGLGTDIGGSIRIPSAFCGI 259

  Fly   195 VGLKPTYGLVSRHGLIPLVNS----MDVPGIFARSVSDCVAVLNTVAGPD--KLDSTTIRQPFTR 253
            .|.|||...:|..|:...|..    :...|..||.|......:..:...|  .||.|....||.:
Zfish   260 CGFKPTARRLSTRGIDTCVKGQKSVLSSIGPLARDVESLALCMRALLCQDMFSLDPTIPPLPFNQ 324

  Fly   254 LHLPEVGQIDLSTVRIGIPKEYHCHG-------LSAEVLETWSKVADLLECSGASVRQVSLPNTA 311
                ||.: ....:|||.   |...|       ::..|.||    .:|||.:|    ...:|  .
Zfish   325 ----EVYE-SSKPLRIGY---YETDGYLQPSPSMARAVRET----KELLERAG----HTFVP--F 371

  Fly   312 ASIFVYTILNQCEVASNMARYDGIEYGHRATDERSTEQLYALSRAEGFNDVVKTRILT-GNFLLL 375
            ..:.:|.|.:  |:|......||            .|.|::..:|...:..:.::.:| |:...:
Zfish   372 QPLRLYNIFH--ELALRGILGDG------------GETLFSHLKAGPLDPCLCSQPVTLGSPRFI 422

  Fly   376 KK----------------------------------NYDHYFEKALRVRRLIAEDFARVFDSSAK 406
            :|                                  |.:.|      ::.:|||  .|..|
Zfish   423 RKMLSFLIKPFFPRISASLHGTCGLGSVAELWRQHANVEEY------IQEVIAE--WRRLD---- 475

  Fly   407 EERVDILLTP---------------TTLTEAPLYK--DF-------ASLTNRDQCAVQ------- 440
               |||||.|               :.|:...||.  :|       :::|..|:..::
Zfish   476 ---VDILLCPILGPAFNFHYCGRLNSALSYTTLYNLLNFPAGVVCVSAVTEDDEAQLRQYTGAHG 537

  Fly   441 ---DFCTQPANMAGIPAVSIPIRLSQAGLPLSLQLMSNSLNEQLLLTVARWIE 490
               |...|.|...|:            |||:::|.:|....:::.|...|.:|
Zfish   538 DPWDKLFQQAVKGGV------------GLPVAVQCVSLPWQDEMCLRFMREVE 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GatA	NP_650775.2	PRK07488	8..491	CDD:236030	137/573 (24%)
GatA	NP_650775.2	gatA	18..490	CDD:234572	133/561 (24%)
faah	NP_001103295.1	Amidase	101..571	CDD:302749	126/542 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810