DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dnk and TK2

DIOPT Version :9

Sequence 1:	NP_001262722.1	Gene:	dnk / 42273	FlyBaseID:	FBgn0022338	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_004605.4	Gene:	TK2 / 7084	HGNCID:	11831	Length:	265	Species:	Homo sapiens

Alignment Length:	214	Identity:	97/214 - (45%)
Similarity:	137/214 - (64%)	Gaps:	2/214 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWA 77
            |..|..:...:.:||||.|||||.|..|.. ..|:.:|||||.|||||.|.|.|.|||.|..:|.
Human    43 KEQEKEKKSVICVEGNIASGKTTCLEFFSN-ATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWG 106

  Fly    78 MPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEES 142
            :..|:||.||||..||.|....:::|||||.||||.||||:.|:|.:.:..|..|.||:.:|..:
Human   107 LTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRN 171

  Fly   143 IHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIH-QRRPQSCKVLVLD 206
            :.|..|||:||||:||..|:|:::|.|.||..:||:||:.:|.|||:|||. ...|.:..|||::
Human   172 MDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIE 236

  Fly   207 ADLNLENIGTEYQRSESSI 225
            ||.::|.:...::::...|
Human   237 ADHHMERMLELFEQNRDRI 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnk	NP_001262722.1	dNK	23..214	CDD:238836	94/191 (49%)
dnk	NP_001262722.1	DTMP_kinase	23..214	CDD:161676	94/191 (49%)
TK2	NP_004605.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..47		1/3 (33%)
		dNK	53..265	CDD:279974	95/204 (47%)
		DTMP_kinase	53..238	CDD:161676	91/185 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145127
Domainoid	1	1.000	193	1.000	Domainoid score	I3211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3392
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3836
Isobase	1	0.950	-	0	Normalized mean entropy	S6389
OMA	1	1.010	-	-		QHG54257
OrthoDB	1	1.010	-	-		D1505356at2759
OrthoFinder	1	1.000	-	-		FOG0001503
OrthoInspector	1	1.000	-	-		oto90986
orthoMCL	1	0.900	-	-		OOG6_102194
Panther	1	1.100	-	-	LDO	PTHR10513
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4541
SonicParanoid	1	1.000	-	-		X6020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.850