DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnk and tk2

DIOPT Version :9

Sequence 1:	NP_001262722.1	Gene:	dnk / 42273	FlyBaseID:	FBgn0022338	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001016888.1	Gene:	tk2 / 549642	XenbaseID:	XB-GENE-983640	Length:	274	Species:	Xenopus tropicalis

Alignment Length:	223	Identity:	99/223 - (44%)
Similarity:	143/223 - (64%)	Gaps:	4/223 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLEL 68
            ::..|..|.|:.|  :...:.:||||.||||:.|:.|.. ..|:.:..|||.|||||.|.|.|.|
Frog    52 SSGSAGNGLKHRE--KSTLICVEGNIASGKTSCLDFFSN-TADLEVYKEPVAKWRNVRGHNPLGL 113

  Fly    69 MYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLE 133
            ||:||.||.:..|:||.||||..||.|:...:|:|||||:||:|.||||:.::|.:.:..|..|.
Frog   114 MYQDPNKWGLTLQTYVQLTMLDIHTKPSISPVKMMERSIYSAKYIFVENLYQSGKMPEVDYAILT 178

  Fly   134 EWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRR-P 197
            ||:::|.::.....|||:||:||||..|:|:::|.|.||..:||:||..:|.|:||||:.|.. |
Frog   179 EWFEWIVKNTDTSVDLIVYLQTSPETCYQRLKKRCREEERVIPLEYLYAIHNLYEDWLVKQTSFP 243

  Fly   198 QSCKVLVLDADLNLENIGTEYQRSESSI 225
            ....|||:||:..||.:...|:.:..||
Frog   244 VPAPVLVIDANKELEEMNRHYEENRGSI 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnk	NP_001262722.1	dNK	23..214	CDD:238836	92/191 (48%)
dnk	NP_001262722.1	DTMP_kinase	23..214	CDD:161676	92/191 (48%)
tk2	NP_001016888.1	DTMP_kinase	65..259	CDD:161676	91/194 (47%)
tk2	NP_001016888.1	dNK	69..273	CDD:279974	95/204 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3272
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3392
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3670
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1505356at2759
OrthoFinder	1	1.000	-	-		FOG0001503
OrthoInspector	1	1.000	-	-		oto104774
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4541
SonicParanoid	1	1.000	-	-		X6020
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090